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Hilzenrat, Nir; Zilberman, Doron; Klein, Tirza; Zur, Boaz; Sikuler, Emanuel

doi:10.1023/a:1026645629103

Cited by 37 publications

(5 citation statements)

References 7 publications

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“…To our knowledge, on a global scale, a total number of 9 well-documented cases (including ours) suggest HAV infection as a trigger factor for AIH [9, 10, 11, 13, 14, 15, 27](table 1). Seven out of the 9 cases were women, which is in line with the expected gender distribution in AIH.…”

Section: Discussionmentioning

confidence: 86%

Autoimmune Hepatitis – Sequel of a Relapsing Hepatitis A in a 75-Year-Old Woman

Grünhage¹,

Spengler²,

Fischer³

et al. 2004

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Acute hepatitis A virus (HAV) infection is a global cause of acute hepatitis. However, chronic HAV infection is unlikely. Nevertheless, there is some evidence that acute infection with HAV may trigger chronic active hepatitis which fulfils the criteria of autoimmune hepatitis (AIH). Whether AIH following HAV infection is virus specific remains unclear. Despite evidence that inherited factors may play a role in the development of autoimmunity after viral infection, the pathomechanism remains unclear. We describe a 75-year-old woman with a history of pulmonary sarcoidosis who developed AIH after acute HAV infection.

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Section: Discussionmentioning

confidence: 86%

Autoimmune Hepatitis – Sequel of a Relapsing Hepatitis A in a 75-Year-Old Woman

Grünhage¹,

Spengler²,

Fischer³

et al. 2004

Digestion

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“…In auto-immune hepatitis patients, HLA DRB positive patients are more likely to have the disease than other patients [7]. Although, drugs and toxins may theoretically affect immune homeostasis and trigger AIH, primarily viruses have been studied in this context [8]. …”

Section: Introductionmentioning

confidence: 99%

HLA-DRB1 as a risk factor in children with autoimmune hepatitis and its relation to hepatitis A infection

et al. 2010

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BackgroundThe human leukocyte antigens (HLAs) are proteins found in the membranes of nearly all nucleated cells. People with certain HLA antigens are more likely to develop certain autoimmune diseases. The aim of this study was to determine the frequency of HLA-DRB1 in children with autoimmune hepatitis (AIH) as a risk factor for occurrence, its relation to preceding hepatitis A infection and treatment outcome.Subjects and methods25 children with AIH were subjected to HLA-DRB 1 typing performed by sequence specific oligonucleotide probe technique and compared to HLA-DRB1 found in 548 normal populations.ResultsThe most frequent alleles found in our children with AIH were HLA-DRB1*13 (36%), HLA-DRB1*04 (18%) and HLA-DRB1*03 (14%). HLA-DRB1*13 was significantly more frequent in AIH patients compared to controls. In type I AIH patients HLA-DRB1*13 was the most frequent allele (32.4%), followed by HLA-DRB1*04 in (20.6%) and HLA-DRB1*03 in (14.7%), While in type II, the most frequent alleles were HLA-DRB1*13 in (40%), HLA-DRB1*07 (20%) and HLA-DRB1*15 in (20%). HLA-DRB1*12 was significantly more frequent in AIH patients with positive Hepatitis A IgM than in patients with negative hepatitis A IgM. No statistically significant difference between partial responders and complete responders to treatment as regards HLA-DRB1 subtypes.ConclusionIt is concluded from the previous study that HLA-DRB1*13 may be a susceptibility allele for the occurrence of autoimmune hepatitis in our population. HLA-DRB1*07 and HLA-DRB1*15 may be susceptibility alleles for occurrence of autoimmune hepatitis type 2. HLA-DRB1*12 association with AIH in patients triggered by hepatitis A needs further studies.

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“…In particular, patients with DRB1*0301 alleles are more prone to a more serious form of disease than patients who possess 0401 alleles [ 10 , 11 ]. The DRB1*0401 gene was identified from a case report of AIH after hepatitis A by Hilzenrat et al [ 12 ] in 1999. The patient did not show progression to a severe state, which suggested that acute hepatitis A can trigger AIH in genetically susceptible patients.…”

Section: Discussionmentioning

confidence: 99%

Acute Hepatitis A-Induced Autoimmune Hepatitis: A Case Report and Literature Review

Kim

Yoo

et al. 2022

Medicina

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Introduction: The pathogenesis of autoimmune hepatitis (AIH) is little known. Previous case reports suggest that several viral hepatitis, including hepatitis A, can trigger AIH. Patient: A 55-year-old female showed general weakness and jaundice. The patient was diagnosed with acute hepatitis A and discharged after 14 days of hospitalization with improving liver function. However, blood tests performed 6 days after discharge revealed an increase in liver enzymes and high serum titers of an anti-nuclear antibody and immunoglobulin G. She was readmitted for liver biopsy. Diagnosis: Liver biopsy showed acute hepatitis A along with AIH. According to the revised international autoimmune hepatitis group scoring system, her score was 14 and she was diagnosed as AIH induced by acute hepatitis A. Intervention: Conservative treatments with crystalloid (Lactated Ringer’s Solution), ursodeoxycholic acid, and silymarin were administered. Outcomes: The patient has been followed up on an outpatient basis and neither symptom recurrence nor an increase in liver enzymes has been reported thus far. Lessons: After the treatment of acute hepatitis A, liver function needs to be carefully monitored over time, and the possibility of autoimmune hepatitis should be considered when liver enzymes increases.

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Cited by 37 publications

References 7 publications

Autoimmune Hepatitis – Sequel of a Relapsing Hepatitis A in a 75-Year-Old Woman

Autoimmune Hepatitis – Sequel of a Relapsing Hepatitis A in a 75-Year-Old Woman

HLA-DRB1 as a risk factor in children with autoimmune hepatitis and its relation to hepatitis A infection

Acute Hepatitis A-Induced Autoimmune Hepatitis: A Case Report and Literature Review

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