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Даев, Е. В.

doi:10.1023/a:1026122926802

Cited by 3 publications

(2 citation statements)

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“…Smelling DMP also induces immune suppression in mice: the quantity of antibody-producing cells is reduced as under physical stress, and the chromosome aberration level in bone marrow dividing cells is increased (Daev et al, 2007a). All these data, together with the DMP-dependent inhibition of reproduction (Daev, 2003), indicate the action of the pheromone as a powerful stressor in mice. It is suggested that 2,5-dimethylpyrazine (DMP) inhibits the maturation of juvenile mice in a population and may function when the living conditions are below the optimal level for reproduction (Jemiolo and Novotny, 1994).…”

Section: Introductionmentioning

confidence: 78%

“…Therefore, the increased level of sperm head abnormalities is likely the result of the microdamaging mutagenic action of DMP-induced stress on meiotic spermatocytes. This is especially important since it is known that DMP and some other pheromonal treatments of the recipient mouse males induce lethality in their progeny after mating with intact females (Daev, 2003(Daev, , 2008. The reproductive ability of stressed males was checked by mating with intact females 36-42 days after the exposure to pheromones or 18-22 days after the exposure to DMP.…”

Section: Discussionmentioning

confidence: 99%

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Pheromonal effects on germ cells of house mouse males: possible evolutionary consequences

Даев

2019

BioComm

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It is well known that in mice some pheromones modify reproductively important features. But the genetic mechanisms underlying such changes remain insufficiently studied. Here we show that in laboratory mice (Mus musculus L.), volatile signal 2,5-dimethylpyrazine excreted by donor stressed females increases the level of structural chromosome aberrations and other meiotic disturbances in spermatocytes of recipient males after nasal contact with the volatiles via sniffing. These chemosignals (i.e. pheromones) also induce abnormalities of sperm heads in the recipient mice. We assume that visible macro-damages at the chromosome level in meiotic cells are marks of a more widely disturbing effect (not only macro-but also micro-damages) of some olfactory signals in meiotic cells. It is most probable that the effects of volatile cues are mediated by the nervous system of the recipient organism. While gross chromosomal aberrations lead mainly to death of damaged cells, some of them (micro-damages of the chromosomes) might reach spermatozoa, and we detected part of them as anomalous sperm heads. Such abnormalities can reduce the fertilizing capacity of sperm. Moreover, some of the mutations induced by density-dependent volatile chemosignals can reach the progeny and influence the quantity and genetic quality of future generations. Possible microevolutionary consequences are discussed.

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Section: Introductionmentioning

confidence: 78%

Section: Discussionmentioning

confidence: 99%