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Shevchenko, V. P.; Nagaev, I. Yu.; Myasoedov, N. F.

doi:10.1023/a:1022333905411

Cited by 7 publications

(18 citation statements)

References 1 publication

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“…The improved isotopic exchange in this case can be explained via a back spillover process that leads to protonated water clusters cluster growth from 1 to 3 molecules (n ¼ 12163:1, n ¼ 22196:6, n=3À220.7 kcal/mol). 6 So, minimizing the tritiated water content in the solution to a reasonable value and careful drying of solvents, catalyst and substrate are necessary not only to prevent the isotopic dilution, 7 but also to decrease the effective size of water clusters on the surface of the catalyst thus increasing the efficiency of the isotopic exchange process. Finally, the specific activity of the resulting compound depends upon the competition between the tritiated water and the substrate molecules on the active centers, and in some cases optimization of the substrate-catalysttritiated water ratio is necessary.…”

Section: Resultsmentioning

confidence: 99%

Synthesis of selectively labeled fatty acids and tritium labeled acyl‐CoA and CoA

Шевченко

Nagaev

Безуглов

et al. 2007

Labelled Comp Radiopharmac

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Zinc(II)‐dithizone based molecular systems [Zn(HDz)2] are intriguing candidates for the development of optical devices thanks to their interesting photochromic and nonlinear optical properties. In the present work, the behavior of Zn(HDz)2 in different solvents was investigated by a combined theoretical and experimental approach. In particular, solutions of both dithizone (H2Dz) and Zn(HDz)2 were analyzed by optical absorption spectroscopy and nuclear magnetic resonance (NMR) techniques, with particular attention to structure–properties relationships. Density functional and time‐dependent density functional calculations were performed on the stable and the activated forms of the complex, obtaining information on the energetics of their interconversion, as well as on the nature of their electronic excitations. Copyright © 2007 John Wiley & Sons, Ltd.

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Section: Resultsmentioning

confidence: 99%

Synthesis of selectively labeled fatty acids and tritium labeled acyl‐CoA and CoA

Шевченко

Nagaev

Безуглов

et al. 2007

Labelled Comp Radiopharmac

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“…37 In the case of amino acids, the use of an additional support also promoted an increase in the molar radioactivity (Tables 1 and 13). Activated carbon, alumina and calcium carbonate are used most often.…”

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confidence: 95%

“…For example, rhodium salts were used in the labelling of amino acids. 30,37 It was shown that RhCl 3 not only stabilizes labile compounds but also simultaneously, modifies the initiator of hydrogen spillover. Apparently, coprecipitation of rhodium salts on palladium with subsequent heating under an atmosphere of tritium gas gives rise to bimetallic active sites, which acquire new properties of both an adsorbent and an initiator of hydrogen spillover.…”

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confidence: 99%

Solid‐phase reactions as approach to the synthesis of organic compounds labelled with tritium

Myasoedov

2007

Labelled Comp Radiopharmac

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The solid-phase method for hydrogenolysis, hydrogenation and isotope exchange reactions is described. Its potential for tritium labelling of organic compounds including lipids, nucleotides, amino acids, peptides and pharmaceuticals is demonstrated. The influence of the reaction conditions on the yield and specific radioactivity of the labelled compounds is considered. It is shown that results can be interpreted by the dependence of tritium spillover reactions on the nature of the initial compound and other factors.

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“…Probably, the role of the catalyst in this procedure is merely the weakening of the R-H bond, increasing the probability of tritium incorporation [12]. Therefore, even with 100% tritium water, the molar radioactivity of the labeled products was as low as several units or DOI: 10.1134/S1066362212010122 Scheme 1.…”

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confidence: 99%

Tritium labeling of bioorganic compounds by isotope exchange

2012

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Procedures for preparing labeled compounds by liquid-and solid-phase methods using gaseous tritium and by isotope exchange with tritium water are considered as different manifestations of a common complex of processes occurring in the presence of tritium, a substrate, and a catalyst. The studies performed allow purposeful optimization of the conditions of tritium labeling of practically any biologically active substance, which makes possible more detailed investigation of the functioning of living objects.

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Cited by 7 publications

References 1 publication

Synthesis of selectively labeled fatty acids and tritium labeled acyl‐CoA and CoA

Synthesis of selectively labeled fatty acids and tritium labeled acyl‐CoA and CoA

Solid‐phase reactions as approach to the synthesis of organic compounds labelled with tritium

Tritium labeling of bioorganic compounds by isotope exchange

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