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Konířová, R.; Kohlíčková, M.; Jedináková-Křížová, V.

doi:10.1023/a:1006757410622

Cited by 12 publications

(6 citation statements)

References 5 publications

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“…The ratio of Sn 2+: Re 7+ concentrations should not be lower than 10: 1. This ratio is 80 times lower than that recommended in a number of other studies (800: 1) [1][2][3].…”

Section: Discussioncontrasting

confidence: 56%

“…The concentrations of Sn 2+ and of the 188 Re carrier in a reaction mixture influence significantly the radiochemical yield of 188 Re complex. A number of researchers believe that for effective reduction of 188 ReO 4 -the molar ratio of SnCl 2 and NaReO 4 should be 800: 1 [1][2][3]. The presence of an antioxidant (ascorbic or gentisic acid) in the reaction mixture is necessary for increasing the stability of the formed complex [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

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Influence of the rhenium carrier in eluate of Re-188 on its binding with potassium-sodium salt of hydroxyethylidene biphosphonic acid

et al. 2006

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The results of investigation of the regularity of 188 Re binding with KNaHEDP and hydrolysis of the complex compound ( 188 Re-KNaHEDP) have shown that its quality depends to a considerable extent on the reaction conditions. Concentrations of a reducing agent (Sn 2 + ) and stable rhenium in the 188 Re eluate, as the carrier, influence essentially the rate of formation and stability of 188 Re complex with KNaHEDP. The results of the kinetic investigations of the 188 Re-KNaHEDP complex formation prove that the reaction character bears a direct relationship to the concentrations of the complexing agent (Re) and the reducer (Sn 2+ ).The higher ratio of Re 7+ : Sn 2+ concentrations, the more effectively 188 Re binds with KNaHEDP. The obtained results prove that for 188 Re binding with KNaHEDP with the efficiency not less than 95 % the optimum concentration of stable rhenium in the reaction mixture is 0.54×10 -6 mol . ml -1 (0.1 mgΜml -1 ) and the ratio of Re 7+ : Sn 2+ concentrations should not be lower than 10: 1.

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“…The ratio of Sn 2+: Re 7+ concentrations should not be lower than 10: 1. This ratio is 80 times lower than that recommended in a number of other studies (800: 1) [1][2][3].…”

Section: Discussioncontrasting

confidence: 56%

Section: Introductionmentioning

confidence: 99%

Influence of the rhenium carrier in eluate of Re-188 on its binding with potassium-sodium salt of hydroxyethylidene biphosphonic acid

et al. 2006

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“…This ratio is 80 times lower than that recommended in a number of other studies (800: 1) [1][2][3]. Concentrations of the reducing agent (Sn 2+ ) and stable rhenium in the 188 Re eluate as the carrier considerably influence the rate of formation and stability of the 188 Re-KNaHEDP complex.…”

Section: Discussionmentioning

confidence: 65%

Influence of the rhenium carrier in eluate of Re-188 on its binding with potassium-sodium salt of hydroxyethylidene biphosphonic acid

Петриев¹,

Afanasieva²,

Скворцов³

et al. 2006

Czech J Phys

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“…The addition of ascorbic acid (as an antioxidant) to the reaction mixture was tested, because it is known, both from the literature and experimental evidence [2][3][4][5][6]14], that ascorbic acid helps to keep stronger reducing environment for dissolved rhenium in lower oxidation state. The addition of ascorbic acid (as an antioxidant) to the reaction mixture was tested, because it is known, both from the literature and experimental evidence [2][3][4][5][6]14], that ascorbic acid helps to keep stronger reducing environment for dissolved rhenium in lower oxidation state.…”

Section: Influence Of Ascorbic Acid As Antioxidantmentioning

confidence: 99%

“…The molar excess of stannous chloride over perrhenate in the reaction mixture should be about 800 for obtaining successful reduction of perrhenate with subsequent complexation [1][2][3]. belong to a large group of radiopharmaceuticals applicable in radiotherapy.…”

Section: Introductionmentioning

confidence: 99%

Study of perrhenate reduction by capillary electrophoresis

Kohlíčková-Koudelková

Jedináková-Křížová

Deyl

2002

Electrophoresis

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The influence of perrhenate concentration, the concentration of the reducing agent and pH of the reaction mixture on the yield of perrhenate reduction were studied to find a possibility to decrease the stannous chloride concentration in the reaction mixture without negative changes on the yield of perrhenate reduction. Britton-Robinson buffer solutions were selected as the background electrolytes because of their buffering capacity in a wide pH interval. The highest degree of perrhenate reduction was obtained at pH 2 at perrhenate concentrations ranging from 10(-4) to 10(-3) mol/L. The stability of reduced rhenium against pH change from 2 to 5.5 and against dilution of rhenium in the reaction mixture to the concentration suitable for the application in radiotherapy were studied as well. The results obtained by capillary electrophoresis and by thin-layer chromatography with radiometric detection were compared.

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Cited by 12 publications

References 5 publications

Influence of the rhenium carrier in eluate of Re-188 on its binding with potassium-sodium salt of hydroxyethylidene biphosphonic acid

Influence of the rhenium carrier in eluate of Re-188 on its binding with potassium-sodium salt of hydroxyethylidene biphosphonic acid

Influence of the rhenium carrier in eluate of Re-188 on its binding with potassium-sodium salt of hydroxyethylidene biphosphonic acid

Study of perrhenate reduction by capillary electrophoresis

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