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Abstract

The National Research Programme "Innovative Low-Toxic Bioactive Systems for Precision Medicine (BioActiveMed)" was approved by DCM №658/14.09.2018 and is performed on the basis of a signed agreement Grant DO1-217/30.11.2018 between Ministry of Education and Science and Bulgarian Academy of Sciences (BAS). A prerequisite for the implementation of the NRP BioActiveMed is the fact that Bulgaria, with its unique climatic and ecological factors, offers an amazing variety of plant and animal species. Isolated extracts contain a series of bioactive compounds that resembles combined therapy with several synthetic compounds. It is well known that extracts from natural products are less toxic than synthetic and are better tolerated by the human body. Therefore, the proposed in the Programme approach is one of the key to overcoming multiple drug resistance.The Programme is focused on the development of new low toxic bioactive substances and systems containing extracts of natural sources (of plant or animal origin) from Bulgaria for the prevention and support of the therapy of certain diseases. The first step is the isolation and purification of bioactive substances of plant and animal origin, their appropriate incorporation in suitable innovative systems and development of new methodologies for their characterization and determination of quality and applicability as new products in personalized and preventative medicine. One of the planned long-term applications is the implementation of new innovative healthy and safe food supplements and cosmetics with a preventive potential for personalized medicine.The research has been carried out with the participation of leading scientists with proven scientific capacity, as well as with the active participation of young scientists and PhD students from the Consortium formed. The leading organization is the Bulgarian Academy of Sciences and the following scientific organizations (seven scientific units from the BAS) and higher education organizations with the highest capacity in the field of the Programme are