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Abstract

Background: Diagnosis of zoonotic infection is important when history of patient indicating animal contact is obvious especially with respect to Leptospirosis and Brucellosis. The present study is necessary to increase our knowledge and help the society to make necessary interventions which will help to control the morbidity and mortality in the region. Aim: To study brucellosis and leptospirosis among patients with pyrexia of unknown origin. Materials and Methods: A total of 111 patients diagnosed as PUO were studied. Leptospirosis was diagnosed with Anti-leptospiral IgM antibody ELISA, IgG and IgM ELISA were used to detect Brucellosis. All samples were tested with standard agglutination test for Brucellosis. Results: 2 out of 111 patients, i.e. 1.80% showed the presence of Anti Leptospiral antibodies. Samples from 111 patients enrolled in present study and 50 from the control group where subjected to IgG and IgM ELISA for Brucellosis. Anti-Brucella IgM antibodies were found in 2 (1.80%) and IgG in 4 (3.60%). Samples from patients in the study group were subjected to standard agglutination test along with control group samples. 3 patients (2.7%) out of 111 patients were positive by SAT. Conclusion: As clinical symptoms of zoonotic infections such as Brucellosis and Leptospirosis are not specific and are present as PUO, it is beneficial to include diagnostic test such as IgG ELISA and IgM ELISA for Brucellosis and Leptospirosis in the battery of test for PUO.