Untitled

Abstract

View the peer-reviewed version (peerj.com/articles/612), which is the preferred citable publication unless you specifically need to cite this preprint. eukaryotic cells. However, we were unable to derive analogs without cytotoxicity; all compounds synthesized were cytotoxic (TC50 of 0.1-5 µM). We conclude that cytotoxicity is a liability in this series precluding it from further development. However, the series has potent anti-tubercular activity and future efforts towards identifying the mode of action could result in the identification of novel drug targets.PeerJ PrePrints | http://dx.doi.org/10.7287/peerj.preprints.502v1 | CC-BY 4.0 Open Access |