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Aa, E.M. van der; Peereboom-Stegeman, J.H.J. Copius; Noordhoek, J.; Gribnau, F. W. J.; Rüssel, Frans G. M.

doi:10.1023/a:1008656928861

Cited by 100 publications

(42 citation statements)

References 106 publications

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“…Passive diffusion is often the mechanism by which chemicals cross the placental barrier (Syme et al 2004), so the TTE of hydrophilic compounds is generally lower than for hydrophobic compounds (Van der Aa et al 1998). Based on earlier elution in reverse-phase chromatography, branched PFOS isomers are anticipated to be more hydrophilic than linear PFOS, and short-chain carboxylates (e.g., PFOA) should be more hydrophilic than longer-chain carboxylates (e.g., PFNA and PFDA), so the present results are unexpected.…”

Section: Resultsmentioning

confidence: 99%

Isomer Profiles of Perfluorochemicals in Matched Maternal, Cord, and House Dust Samples: Manufacturing Sources and Transplacental Transfer

Beesoon

Webster

Shoeib

et al. 2011

Environ Health Perspect

173

146

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Background: Perfluorochemicals (PFCs) are detectable in the general population and in the human environment, including house dust. Sources are not well characterized, but isomer patterns should enable differentiation of historical and contemporary manufacturing sources. Isomer-specific maternal–fetal transfer of PFCs has not been examined despite known developmental toxicity of perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) in rodents.Objectives: We elucidated relative contributions of electrochemical (phased out in 2001) and telomer (contemporary) PFCs in dust and measured how transplacental transfer efficiency (TTE; based on a comparison of maternal and cord sera concentrations) is affected by perfluorinated chain length and isomer branching pattern.Methods: We analyzed matching samples of house dust (n = 18), maternal sera (n = 20), and umbilical cord sera (n = 20) by isomer-specific high-performance liquid chromatography tandem mass spectrometry.Results: PFOA isomer signatures revealed that telomer sources accounted for 0–95% of total PFOA in house dust (median, 31%). This may partly explain why serum PFOA concentrations are not declining in some countries despite the phase-out of electrochemical PFOA. TTE data indicate that total branched isomers crossed the placenta more efficiently than did linear isomers for both PFOS (p < 0.01) and PFOA (p = 0.02) and that placental transfer of branched isomers of PFOS increased as the branching point moved closer to the sulfonate (SO3–) end of the molecule.Conclusions: Results suggest that humans are exposed to telomer PFOA, but larger studies that also account for dietary sources should be conducted. The exposure profile of PFOS and PFOA isomers can differ between the mother and fetus—an important consideration for perinatal epidemiology studies of PFCs.

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Section: Resultsmentioning

confidence: 99%

Isomer Profiles of Perfluorochemicals in Matched Maternal, Cord, and House Dust Samples: Manufacturing Sources and Transplacental Transfer

Beesoon

Webster

Shoeib

et al. 2011

Environ Health Perspect

173

146

View full text Add to dashboard Cite

show abstract

“…Based on lipophilicity, it is seems likely though that MPTP will pass easily through the placenta at all times of development. Conversely, being a charged species, it is unlikely that MPP+ would pass to any significant extent from the maternal to the fetal circulation (van der Aa, et al, 1998). The blood-brain and blood-CSF barriers appear well established even at the earliest stages of development (Ek, et al, 2012, Saunders, et al, 2000).…”

Section: Discussionmentioning

confidence: 99%

Susceptibility to a parkinsonian toxin varies during primate development

Morrow

Roth

Redmond

et al. 2012

Experimental Neurology

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Symptoms of Parkinson’s disease typically emerge later in life when loss of nigrostriatal dopamine neuron function exceeds the threshold of compensatory mechanisms in the basal ganglia. Although nigrostriatal dopamine neurons are lost during aging, in Parkinson’s disease other detrimental factors must play a role to produce greater than normal loss of these neurons. Early development has been hypothesized to be a potentially vulnerable period when environmental or genetic abnormalities may compromise central dopamine neurons. This study uses a specific parkinsonian neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), to probe the relative vulnerability of nigrostriatal dopamine neurons at different stages of primate development. Measures of dopamine, homovanillic acid, 1-methyl-pyridinium concentrations and tyrosine hydroxylase immunoreactive neurons indicated that at mid-gestation dopamine neurons are relatively vulnerable to MPTP, whereas later in development or in the young primate these neurons are resistant to the neurotoxin. These studies highlight a potentially greater risk to the fetus of exposure during mid-gestation to environmental agents that cause oxidative stress. In addition, the data suggest that uncoupling protein-2 may be a target for retarding the progressive loss of nigrostriatal dopamine neurons that occurs in Parkinson’s disease and aging.

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“…Because cyclosporine can cross the placental barrier, it may exert adverse effects on the fetus[71]. In renal transplant patients, cyclosporine caused premature birth, low birth weight, gestational diabetes, maternal hypertension, pre-eclampsia and fluctuations in the levels of other drugs[72].…”

Section: Medical Treatmentmentioning

confidence: 99%

Treatment of pregnant women with a diagnosis of inflammatory bowel disease

Poturoğlu¹,

Örmeci²,

Duman³

2016

WJGPT

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The frequency of diagnosis of inflammatory bowel disease (IBD) has increased in younger populations. For this reason, pregnancy in patients with IBD is a topic of interest, warranting additional focus on disease management during this period. The main objective of this article is to summarize the latest findings and guidelines on the management of potential problems from pregnancy to the breastfeeding stage. Fertility is decreased in patients with active IBD. Disease remission prior to conception will likely decrease the rate of pregnancy-related complications. Most of the drugs used for IBD treatment are safe during both pregnancy and breastfeeding. Two exceptions are methotrexate and thalidomide, which are contraindicated in pregnancy. Anti-tumor necrosis factor agents are not advised during the third trimester as they exhibit increased transplacental transmission and potentially cause immunosuppression in the fetus. Radiological and endoscopic examinations and surgical interventions should be performed only when absolutely necessary. Surgery increases the fetal mortality rate. The delivery method should be determined with consideration of the disease site and presence of progression or flare up. Treatment planning should be a collaborative effort among the gastroenterologist, obstetrician, colorectal surgeon and patient.

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Untitled

Cited by 100 publications

References 106 publications

Isomer Profiles of Perfluorochemicals in Matched Maternal, Cord, and House Dust Samples: Manufacturing Sources and Transplacental Transfer

Isomer Profiles of Perfluorochemicals in Matched Maternal, Cord, and House Dust Samples: Manufacturing Sources and Transplacental Transfer

Susceptibility to a parkinsonian toxin varies during primate development

Treatment of pregnant women with a diagnosis of inflammatory bowel disease

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