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Chiron, Hélène; Drouet, A.; Claudot, Anne-Catherine; Eckerskorn, Christoph; Trost, Monika; Heller, Werner; Ernst, D.; Sandermann, Heinrich

doi:10.1023/a:1026507707186

Cited by 75 publications

(12 citation statements)

References 27 publications

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“…2'-Methyl analog 57 showed a higher receptor affinity than Raloxifene. Replacement of the 2-aryl group by a methyl (58), isopropyl (59), 2'-thienyl (60) or 4-hydroxybenzyl group (61) largely preserved binding affinity, whereas replacement by a cyclohexyl (62) 35 30 Katzenellenbogen and coworkers prepared three fluoroalkyl Raloxifene analogs as model systems for 18 F labeled SERMs that can be used as imaging agents for positron emission tomography (PET). 1-Fluoro-ethyl and propyl chains were attached to the 2'-position of Raloxifene.…”

Section: Rba Er (%) Rba Er (%) /mentioning

confidence: 99%

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Non-Steroidal Subtype Selective Estrogens

Veeneman¹

2005

CMC

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The biological effects of estrogens are thought to be mediated by two receptors referred to as ERalpha and ERbeta. In recent years significant efforts have been devoted to the design of subtype selective ligands. These ligands are valuable tools to establish the precise biological role of each of the subtypes and to develop new generations of therapeutics. The first part of this review briefly summarizes the biology behind the estrogen receptors. The second part addresses the structure-activity relationship of the subtype selective ER ligands that were reported up to now. In the third part, the current insights in the therapeutic prospects of the subtype selective estrogens will be discussed.

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Section: Rba Er (%) Rba Er (%) /mentioning

confidence: 99%

“…Piperidine replacements were also investigated. Isoxazole-type SERMs were disclosed by Chiron [38,62]. It was established that the 4-position was optimal for attachment of the BSC.…”

Section: Pyrazoles/isoxazolesmentioning

confidence: 99%

Non-Steroidal Subtype Selective Estrogens

Veeneman¹

2005

CMC

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“…OMT may play an important regulatory role in plant and animal growth, development, reproduction and defence, and is also implicated in human disease (Li et al 2006; Chiron et al 2000; Yao et al 2003; Fan et al 2005). In invertebrates, most studies of the kinds of OMT focus on farnesoic acid O-methyltransferase (FAMeT).…”

Section: Introductionmentioning

confidence: 99%

A farnesoic acid O-methyltransferase (FAMeT) from Exopalaemon carinicauda is responsive to Vibrio anguillarum and WSSV challenge

Duan

Liu

et al. 2014

Cell Stress and Chaperones

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Methyl farnesoate (MF), an analogue of the insect juvenile hormone III, is believed to play important roles in the regulation of the growth and reproductive development in crustaceans. Farnesoic acid O-methyltransferase (FAMeT) is the key enzyme in the juvenile hormone biosynthetic pathway, involved in the conversion of farnesoic acid (FA) to MF in the final step of MF synthesis. In this study, a FAMeT cDNA (named EcFAMeT) was cloned from the hemocytes of ridgetail white prawn Exopalaemon carinicauda by rapid amplification of cDNA ends (RACE) methods. The full-length cDNA of EcFAMeT was 1,620 bp, including contains a 5′-untranslated region (UTR) of 75 bp, 3′-UTR of 714 bp with a poly (A) tail, an open reading frame (ORF) of 831 bp, encoding a 276-amino-acid polypeptide with the predicted molecular weight of 31.57 kDa and estimated isoelectric point of 4.67. BLAST analysis revealed that amino acids of EcFAMeT shared high identity (75–90 %) with that of other crustaceans. Two conserved signatures domains of Methyltransf-FA superfamily were also identified in EcFAMeT. Real time quantitative RT-PCR analysis indicated that EcFAMeT could be detected in all the tested tissues and strongly expressed in hepatopancreas and ovary of E. carinicauda. After Vibrio anguillarum and WSSV challenge, EcFAMeT transcripts both in hemocytes and hepatopancreas increased significantly in the first 3 h, respectively. The results indicated that EcFAMeT might be associated with the immune defenses to V. anguillarum and WSSV in E. carinicauda.

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“…Thus stat and cata may be involved in protection of protein synthesis. As the only bacteria-to-Arthropoda HGT gene in L. vannamei (Figure 2), omtp was annotated to encode O-methyltransferase, which is ubiquitously dispersed in various organisms and plays an important role in animal growth, development and defense [52,53]. rpc2 is annotated to encode repressor protein C2, which is a gene involved in the SOS response [54,55].…”

Section: Resultsmentioning

confidence: 99%

Horizontally transferred genes in the genome of Pacific white shrimp, Litopenaeus vannamei

Yuan¹,

Zhang²,

Liu³

et al. 2013

BMC Evol Biol

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BackgroundIn recent years, as the development of next-generation sequencing technology, a growing number of genes have been reported as being horizontally transferred from prokaryotes to eukaryotes, most of them involving arthropods. As a member of the phylum Arthropoda, the Pacific white shrimp Litopenaeus vannamei has to adapt to the complex water environments with various symbiotic or parasitic microorganisms, which provide a platform for horizontal gene transfer (HGT).ResultsIn this study, we analyzed the genome-wide HGT events in L. vannamei. Through homology search and phylogenetic analysis, followed by experimental PCR confirmation, 14 genes with HGT event were identified: 12 of them were transferred from bacteria and two from fungi. Structure analysis of these genes showed that the introns of the two fungi-originated genes were substituted by shrimp DNA fragment, two genes transferred from bacteria had shrimp specific introns inserted in them. Furthermore, around other three bacteria-originated genes, there were three large DNA segments inserted into the shrimp genome. One segment was a transposon that fully transferred, and the other two segments contained only coding regions of bacteria. Functional prediction of these 14 genes showed that 6 of them might be related to energy metabolism, and 4 others related to defense of the organism.ConclusionsHGT events from bacteria or fungi were happened in the genome of L. vannamei, and these horizontally transferred genes can be transcribed in shrimp. This is the first time to report the existence of horizontally transferred genes in shrimp. Importantly, most of these genes are exposed to a negative selection pressure and appeared to be functional.

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Cited by 75 publications

References 27 publications

Non-Steroidal Subtype Selective Estrogens

Non-Steroidal Subtype Selective Estrogens

A farnesoic acid O-methyltransferase (FAMeT) from Exopalaemon carinicauda is responsive to Vibrio anguillarum and WSSV challenge

Horizontally transferred genes in the genome of Pacific white shrimp, Litopenaeus vannamei

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