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López, Javier

doi:10.1016/s0957-4271(96)00137-1

Cited by 77 publications

(7 citation statements)

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“…The main vestibular nuclei comprise the descending or inferior (DVN), lateral (LVN), superior (SVN), and medial (MVN) vestibular nuclei (49). Lopez et al, in a study of 15 vestibular nuclei from people aged 40–93, found a neuronal loss of 3% per decade in the vestibular nuclear complex (50, 51). They also found that neuronal loss was higher in the SVN and least in the MVN.…”

Section: The Central Vestibular Systemmentioning

confidence: 99%

“…This study also found that aging had no effect on the volume or length of the vestibular nuclei (49). However, both studies have found an increase in giant neurons in the elderly, related to lipofuscin deposits within the cells (49, 50). Similar studies have been done in animals, with one study showing an age-related decline in the number of neurons of the mouse vestibular nuclei (52).…”

Section: The Central Vestibular Systemmentioning

confidence: 99%

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Age-Related Vestibular Loss: Current Understanding and Future Research Directions

et al. 2016

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The vestibular system sub-serves a number of reflex and perceptual functions, comprising the peripheral apparatus, the vestibular nerve, the brainstem and cerebellar processing circuits, the thalamic relays, and the vestibular cerebral cortical network. This system provides signals of self-motion, important for gaze and postural control, and signals of traveled distance, for spatial orientation, especially in the dark. Current evidence suggests that certain aspects of this multi-faceted system may deteriorate with age and sometimes with severe consequences, such as falls. Often the deterioration in vestibular functioning relates to how the signal is processed by brain circuits rather than an impairment in the sensory transduction process. We review current data concerning age-related changes in the vestibular system, and how this may be important for clinicians dealing with balance disorders.

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Section: The Central Vestibular Systemmentioning

confidence: 99%

Section: The Central Vestibular Systemmentioning

confidence: 99%

Age-Related Vestibular Loss: Current Understanding and Future Research Directions

et al. 2016

View full text Add to dashboard Cite

show abstract

“…The main vestibular nuclei comprise the descending or inferior (DVN), lateral (LVN), superior (SVN), and medial (MVN) vestibular nuclei (49). Lopez et al, in a study of 15 vestibular nuclei from people aged 40-93, found a neuronal loss of 3% per decade in the vestibular nuclear complex (50,51). They also found that neuronal loss was higher in the SVN and least in the MVN.…”

Section: The Central Vestibular Systemmentioning

confidence: 99%

Age-Related Vestibular Loss: Current Understanding and Future Research Directions

Agrawal¹,

Carey²

2017

Frontiers Research Topics

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“…Age-related structural deterioration of central coordination systems for posture and locomotion regulation may be responsible for postural control disturbance [1, 2, 3, 4]. A neuronal loss within the brainstem vestibular nucleus complex and disturbed ventral tracts have been recognized depending on age [2, 3, 4].…”

Section: Introductionmentioning

confidence: 99%

“…A neuronal loss within the brainstem vestibular nucleus complex and disturbed ventral tracts have been recognized depending on age [2, 3, 4]. The older individuals exhibit pontine small infarcts (lacunae) on brain magnetic resonance imaging (MRI).…”

Section: Introductionmentioning

confidence: 99%

Association of Pontine Small Infarction (Lacuna) with Disturbance of Postural Stability

Nagahori

Hirashima²,

Umemura

et al. 2004

Eur Neurol

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Neuronal degeneration within the brainstem has been reported in patients with impaired postural stability. However, the functional significance of these abnormalities is unknown at present. In the present study, we evaluated the relationship between the presence of pontine lacunae and postural stability measured by stabilometry. A total of 209 consecutive patients without neurological signs were divided into three groups according to the territory of lacunae on magnetic resonance imaging: (1) non-lacunar group, (2) pontine lacunar group, and (3) non-pontine lacunar group. Stabilometry was performed and statokinesigram measures including each Romberg quotient were compared among the three groups. Using multivariate analysis, postural stability was found to be disturbed in the pontine lacunar group compared with the other groups. The data of stabilometry in this group were compatible with disturbance of the central controlling system for keeping postural stability. Pontine lacuna is associated with patients with postural instability. This result may be related to the deterioration of the central coordination system for posture and locomotion.

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Cited by 77 publications

References 0 publications

Age-Related Vestibular Loss: Current Understanding and Future Research Directions

Age-Related Vestibular Loss: Current Understanding and Future Research Directions

Age-Related Vestibular Loss: Current Understanding and Future Research Directions

Association of Pontine Small Infarction (Lacuna) with Disturbance of Postural Stability

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