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Abstract

Eosinophilic esophagitis (EoE) and lymphocytic esophagitis (LyE) are inflammatory disorders of esophagus characterized clinically by dysphagia or food impaction. Endoscopical findings like esophageal rings, exudates, furrows and strictures might indicate the presence of these conditions, however, these findings have also been described in other esophageal disorders and endoscopic appearance may be normal in up to 25-30% patients. Inflammation may display a patchy distribution and multiple biopsies from different parts during an endoscopy procedure are required to ensure diagnostic accuracy. Determination of the most appropriate site of the esophagus to obtain a biopsy specimen for diagnosis of EoE or LyE is considered critical. This article highlights issues related to optimal approach to obtaining mucosal biopsies for assessment of EoE and LyE.