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Abstract

ABSTRACT:The aim of this article was to develop pidotimod dispersible tablet and optimize the ingredients for the tablets. The effect of ingredients (diluents, disintegrants and lubricants) on the characteristics of the tablets was evaluated. The pidotimod dispersible tablets were prepared by wet granulation. The effect of diluents on the tablets was investigated by Carr's index, dissolution, hardness, friability and taste. The effect of disintegrants on the tablets was determined by dissolution and cost. And the effect of lubricants on the tablets was studied by weight, hardness and dissolution behavior. The results showed that the optimum proportion was 400mg pidotimod, 120mg MCC, 80mg mannitol, 120mg CMS-Na, 60mg lactose, 20mg aspartame, 10mg magnesium stearate and 6%PVP 50% ethanol solution. Pidotimod dispersible tablets with optimum proportion showed acceptable taste, hardness, friability, dissolution behavior. The preparation process was simple and the tablets could be prepared by ordinary tablet production equipment. So it is suitable for mass industrialized production. The final tableting formulation and the simplified process both had tremendous potentials in commercial large-scale production.

Importance of Urban Green at Reduction of Particulate Matters in Sihwa Industrial Complex, Korea

“…The difference between the PM reduction rates of IC and RA was especially high in August and October. The high PM reduction rate in August seemed to be related not only to PM reduction mechanism of UG but also to an increase of atmospheric mixing height during the summer [27][28][29]. The dispersion of PM occurred rapidly due to active mixing by air turbulence in the summer [28], leading to a minimum PM concentration.…”

“…The high PM reduction rate in August seemed to be related not only to PM reduction mechanism of UG but also to an increase of atmospheric mixing height during the summer [27][28][29]. The dispersion of PM occurred rapidly due to active mixing by air turbulence in the summer [28], leading to a minimum PM concentration. Therefore, it is likely that PM could quickly spread due to the effects of intensive air mixing and prevailing western wind systems, resulting in increasing PM reduction through UG.…”