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Karanikiotis, Charisios; Tentes, Apostolos Anto; Markakidis, S.; Vafiadis, Konstantinos

doi:10.1186/1477-7819-2-37

Cited by 29 publications

(10 citation statements)

References 10 publications

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“…The explanation of this observation may be in serious complications of adrenal metastases, such as bleeding[ 19 ] or adrenal insufficiency due to the presence of a tumor, where reduced steroid hormones production may compromise diagnosis of the primary tumor. [ 20 ]…”

Section: Discussionmentioning

confidence: 99%

Distribution patterns of the metastases of the lung carcinoma in relation to histological type of the primary tumor: An autopsy study

2017

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INTRODUCTION:Lung cancer is among leading causes of death worldwide. Different histological types of the lung carcinoma show significant differences in behavior.OBJECTIVES:The aim of this study is to determine the distribution patterns of metastases of different lung cancer histological types in autopsied individuals.METHODS:Protocols from all autopsies performed at the Institute of Pathology from 2008 till 2014 were reviewed retrospectively, and information on individuals' age, sex, histological type of primary lung cancer, presence and location of metastases, and causes of death were recorded.RESULTS:More than 90% of the individuals with lung cancer metastases were older than 50 years (mean age: 64.5 ± 10.3), with two-fold male predominance. The most frequent histological type in both sexes was adenocarcinoma (48%). Although, in general, hematogenous metastases were mostly found in the liver and adrenal glands, various histological types of lung cancer show specific dissemination patterns. Metastases in adrenal glands derived mostly from adenocarcinoma and large-cell carcinoma. Metastases in the intestines most frequently originated from large-cell carcinoma (P = 0.01). Metastatic complications and bronchopneumonia were the most frequent causes of death.CONCLUSIONS:While, overall, the most frequent hematogenous metastases occur in the liver and adrenal glands, various histological types of lung cancer show specific dissemination patterns. Knowing distribution of metastases is essential for making algorithms of treatment, as well as for improving clinical assessment of the patients with unclear clinical findings and suspicion on occult primary lung cancer.

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Section: Discussionmentioning

confidence: 99%

Distribution patterns of the metastases of the lung carcinoma in relation to histological type of the primary tumor: An autopsy study

2017

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“…However, bilateral adrenal metastases are seen in 10% of all lung cancer patients; of these 2–3% occurs at the time of initial presentation of non-small cell lung cancer. [ 5 ] Studies have shown that bilateral adrenal neoplasms are almost always metastatic tumors rather than primary, and clinical presentation varies with tumor type. [ 6 ] Hence, there was a need for search of a primary elsewhere in the body in our case, even after locating bilateral mass in the adrenal gland.…”

Section: Discussionmentioning

confidence: 99%

Multiple metastatic tumors in the oral cavity

Beena

Panda²,

Heera

et al. 2011

J Oral Maxillofac Pathol

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Metastatic lesions to the oral region are uncommon and account for approximately 1% of all malignant oral tumors. In 25% of the cases, oral metastases are found to be the first sign of the metastatic spread; and in 23% of the cases, it is the first indication of an undiscovered malignancy at a distant site. Metastases to oral soft tissues are even less frequent than jaw bones. Because of its rarity, the clinical presentation of a metastatic lesion in the oral cavity can be deceiving, leading to a misdiagnosis of a benign process; therefore, in any case where the clinical presentation is unusual, especially in patients with a known malignant disease, a biopsy is mandatory. Here, we are presenting a rare case of multiple secondary tumors in the attached gingiva in an otherwise apparently healthy patient with no other symptoms of the primary tumor. It subsequently led to the diagnosis of Pancoast tumor (bronchoalveolar carcinoma) metastasizing simultaneously to multiple sites in the oral cavity and bilateral adrenal glands.

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“…The occurrence of adrenal metastasis in the setting of non-small cell lung cancer (NSCLC) is not uncommon. In patients with NSCLC, the incidence has been reported from 25-40% during the course of the disease [ 1 , 2 ]. Adrenal metastases likely develop via lymphatic spread in early disease and via hematogenous spread in more advanced disease.…”

Section: Discussionmentioning

confidence: 99%

Metastatic adenocarcinoma within a functioning adrenal adenoma: a case report

Martin

Alkhoury

Helton

et al. 2009

Cases J

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We present the case of a 54-year-old woman who underwent right adrenalectomy for palliation of Cushing’s symptoms. She had recently been diagnosed with lung adenocarcinoma. Pathologic findings revealed a 5 cm adrenal adenoma with a metastatic adenocarcinoma deposit. The occurrence of tumor-to-tumor metastasis is rare, and the finding of a metastasis within a functional adrenal adenoma exceptionally so. Previously reported incidences of this finding in patients with lung cancer range from 0.14% to 0.63%. We review the literature regarding this unusual finding.

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Cited by 29 publications

References 10 publications

Distribution patterns of the metastases of the lung carcinoma in relation to histological type of the primary tumor: An autopsy study

Distribution patterns of the metastases of the lung carcinoma in relation to histological type of the primary tumor: An autopsy study

Multiple metastatic tumors in the oral cavity

Metastatic adenocarcinoma within a functioning adrenal adenoma: a case report

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