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Abstract

ABSTRACT:Lead is important heavy metal and due to widespread use in industry, it has become an important pollutant that exerts toxic effects on human health. Lifestyle factors (e.g. cigarette smoking), proximity to industrial areas, lead mines, lead based paints and leaded gasoline significantly contribute to lead pollution of the air, food, water and soil. Several antioxidant enzymes and molecules have been used to evaluate lead-induced oxidative damage. Present study aimed to evaluate the lead acetate induced cardio-toxicity. Lead acetate is known to induce changes in free radical scavenging enzymes like superoxide dismutase (SOD) and catalase (CAT). Healthy looking mice showing no sign of morbidity were divided into three groups. Group I was designated as control whereas group II and group III received lead acetate having doses 10 mg/kg body weight of lead acetate, daily and 150 mg/kg body weight of lead acetate, weekly respectively. Study was performed after 24 hours, 40 and 80 days stages. Lead acetate significantly decrease antioxidant enzymes and increase oxidative stress along with cardiac tissue damage.