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Lafuente, A.; Ai, Esquifino

doi:10.1023/a:1009249410092

Cited by 14 publications

(3 citation statements)

References 32 publications

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“…The decrease in plasma prolactin levels observed after cadmium exposure, agrees with previous data gathered in adult rats after acute or shorter exposures to cadmium (12,14). Cadmium effectively depressed prolactin in both in vivo and in vitro studies (14,15,22).…”

Section: Discussionsupporting

confidence: 89%

“…Cadmium exposure increased plasma ACTH levels, although previous data (12) using other doses of the metal and shorter lengths of metal exposure showed opposite effects. Thus indicating that cadmium effects are dependent on the dose of metal selected and on the duration of the treatment.…”

Section: Discussioncontrasting

confidence: 57%

“…Plasma levels of prolactin, GH and ACTH were determined by specific double-antibody radioimmunoassay (12)(13)(14)(15)(16)(17)(18)(19). …”

Section: Methodsmentioning

confidence: 99%

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Cadmium effects on dopamine turnover and plasma levels of prolactin, GH and ACTH

Lafuente

Márquez

Pazo

et al. 2001

J. Physiol. Biochem.

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This paper analyzes possible dopamine (DA) mediated cadmium effects on plasma levels of prolactin, growing hormone (GH) and adrenocorticotropic hormone (ACTH), and if these changes are related to metal accumulation. For that purpose, adult male rats were treated with 50 mg/L of CdCl2 in the drinking water for one month. Plasma levels of prolactin, ACTH and GH were measured by specific double antibody radioimmunoassays. DA was measured by high performance liquid chromatography using electrochemical detection. Cadmium content in the tissues was measured by atomic absorption spectometry with graphite furnace. Analysis was performed by using a T-Student test. Metal exposure increased DA content (34.79+/-3.06 vs. 18.2+/-2.88 pg/mg protein) and decreased its turnover (0.40+/-0.07 vs. 0.75+/-0.06) in posterior hypothalamus. Cadmium also decreased DA turnover in median eminence (0.48+/-0.15 vs. 1.50+/-0.63). Plasma levels of prolactin and GH decreased (2.4+/-0.11 vs. 3.1+/-0.15 ng/mL and 5.37+/-0.05 vs. 9.87+/-1.8 ng/mL respectively), while those of ACTH increased (2.73+/-0.14 vs. 1.7+/-0.16 ng/mL). Cadmium concentration increased in both hypothalamus (4.88+/-0.34 vs. 0.72+/-0.2 microg/g) and pituitary (22.82+/-4.57 vs. 5.02+/-1.25 microg/g) after the metal exposure. These results suggest that cadmium effects on the secretion of these hormones are not mediated by dopamine and might be correlated to the metal accumulation at pituitary level.

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Section: Discussionsupporting

confidence: 89%

Section: Discussioncontrasting

confidence: 57%

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Cadmium effects on dopamine turnover and plasma levels of prolactin, GH and ACTH

Lafuente

Márquez

Pazo

et al. 2001

J. Physiol. Biochem.

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Effect of cadmium on lymphocyte subsets distribution in thymus and spleen

Lafuente

González-Carracedo

Romero

et al. 2003

J. Physiol. Biochem.

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This work was designed to analyze the possible dose dependent effects of cadmium on the distribution of lymphocyte subsets within the thymus and spleen. Cadmium accumulation was also evaluated in these tissues. For this purpose, adult male rats were exposed for one month to 0, 5, 10, 25, 50 or 100 ppm of cadmium chloride (CdCl2) in the drinking water. In both spleen and thymus, the B lymphocytes increased with the doses of 5 and 10 ppm of CdCl2, and decreased with the doses of 25-100 ppm. In spleen, the doses of 25 and 50 ppm decreased CD4+ cells and the doses of 5 and 10 ppm increased CD8+ cells, while the percentage of thymus T, CD4+, CD8+ and CD4(+)-CD8+ cells was not modified by cadmium treatment at any dose used in this study. After cadmium exposure, the metal was accumulated in the spleen only from the dose of 50 ppm on, and in the thymus, from the dose of 10 ppm on. In conclusion, although the accumulation of the metal is higher in thymus than in spleen, the metal affected CD4+ and CD8+ lymphocytes at the spleen but not at the thymus.

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Cadmium chronotoxicity at pituitary level: effects on plasma ACTH, GH, and TSH daily pattern

et al. 2010

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Cadmium is an endocrine disruptor that has been shown to induce chronotoxic effects. The present study was designed to evaluate the possible cadmium effects on the daily secretory pattern of adrenocorticotropin hormone (ACTH), growth hormone (GH), and thyroid-stimulating hormone (TSH) in adult male Sprague-Dawley rats. For this purpose, animals were treated with cadmium at two different doses [25 and 50 mg/l cadmium chloride (CdCl(2))] in the drinking water for 30 days. Control age-matched rats received cadmium-free water. After the treatment, rats were killed at six different time intervals throughout a 24-h cycle. Cadmium exposure modified the 24-h pattern of plasma ACTH and GH levels, as the peak of ACTH content between 12:00 and 16:00 h in controls appeared at 12:00 h in the group treated with the lowest dose used, while it appeared between 16:00 and 20:00 h in rats exposed to 50 mg/l CdCl(2). In addition, the peak of GH content found at 04:00 h in controls moved to 16:00 h in rats exposed to 25 mg/l CdCl(2), and the highest dose used abolished 24-h changes of GH secretion. The metal treatment did not modify ACTH secretory pattern. Exposure to cadmium also increased ACTH and TSH medium levels around the clock with both doses used. These results suggest that cadmium modifies ACTH and TSH medium levels around the clock, as well as disrupted ACTH and GH secretory pattern, thus confirming the metal chronotoxicity at pituitary level.

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Cited by 14 publications

References 32 publications

Cadmium effects on dopamine turnover and plasma levels of prolactin, GH and ACTH

Cadmium effects on dopamine turnover and plasma levels of prolactin, GH and ACTH

Effect of cadmium on lymphocyte subsets distribution in thymus and spleen

Cadmium chronotoxicity at pituitary level: effects on plasma ACTH, GH, and TSH daily pattern

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