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Kamat, J.P.; Ghosh, Arna; Devasagayam, T.P.A.

doi:10.1023/a:1007048313556

Cited by 98 publications

(33 citation statements)

References 32 publications

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“…Interestingly, it has been proposed that VA possesses 281 chemopreventive properties due to its antioxidant activity and its ability to scavenge free radicals [28]. VA has 282 also been shown to exhibit immunostimulatory effects in enhancing interferon gamma (IFN-γ) secretion and 283 stimulating proliferation of human peripheral blood mononuclear cells [29].…”

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confidence: 99%

Phytochemical uptake following human consumption of Montmorency tart cherry (L. Prunus cerasus) and influence of phenolic acids on vascular smooth muscle cells in vitro

et al. 2015

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confidence: 99%

Phytochemical uptake following human consumption of Montmorency tart cherry (L. Prunus cerasus) and influence of phenolic acids on vascular smooth muscle cells in vitro

et al. 2015

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“…There are reports that MB photosensitization proceeds via a hydroxyl radical-mediated pathway. 13,14) DMMB may also produce hydroxyl radicals. Ferryl hemoglobin may be also another candidate.…”

Section: Discussionmentioning

confidence: 99%

“…Methylene blue (MB) is known to produce not only singlet oxygen but also other ROS. 13,14) Therefore, DMMB, which is a derivative of MB, may also produce ROS other than singlet oxygen. In order to clarify which ROS are involved in virus inactivation and Met-Hb formation by activated monomer or dimer DMMB, the extent of the inactivation and formation in the presence or absence of ROS scavengers, quenchers or enhancer was evaluated.…”

mentioning

confidence: 99%

Involvement of Reactive Oxygen Species in Hemoglobin Oxidation and Virus Inactivation by 1,9-Dimethylmethylene Blue Phototreatment.

Hirayama

Wagner

Abe

et al. 2001

Biological & Pharmaceutical Bulletin

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The viral safety of blood products has been significantly enhanced as a consequence of improvements in donor screening. However, there are still measurable risks of viral transmission through blood products.1,2) Therefore, processes for the removal and/or inactivation of viruses may represent an additional level of safety for these biological materials.Hemoglobin derived from human red blood cells is being used to develop a variety of artificial oxygen carriers. [3][4][5] Out-dated red cells for transfusion are an important source of human hemoglobin for the development of artificial oxygen carriers. The usual techniques for virus removal or inactivation, respectively, in stroma-free hemoglobin (SFH) are filtration and heat-treatment. [6][7][8] However, a combination of at least two techniques, which have different mechanisms of action, is important for complete elimination. This is the approach that has been adopted for the sterilization of a variety of pooled plasma derivatives and could have implications for a pooled hemoglobin product.Photosensitizers have been utillized for virus inactivation of blood products.9,10) We have previously reported on virus photoinactivation in SFH by 1,9-dimethylmethylene blue (DMMB).11) Vesicular stomatitis virus (VSV) was inactivatedϾ6 log 10 by DMMB without Met-Hb formation using 1 mM DMMB and red (655 nm) LED light.11) These conditions favor activation of monomer DMMB, which has an absorption peak of ca. 650 nm. In other experiments, the requirement of oxygen for virus photoinactivation by DMMB was demonstrated by the failure to achieve inactivation in samples bubbled with nitrogen.12)The absorption spectrum of DMMB in aqueous solutions has two peaks, which represent light absorption from the monomer and dimer forms.12) Activation of the dimer (max 590 nm), in contrast to monomer, resulted in virus photoinactivation with photooxidation of hemoglobin to methemoglobin (Met-Hb).11) It was speculated that compared with the dimer, the monomer of DMMB has high affinity to nucleic acids and so inactivates virus without inducing Met-Hb formation. However, why Met-Hb forms on exposure to activated dimer but not monomer may also be explained by a difference in the reactive oxygen species (ROS) involved in the four events (virus inactivation by monomer DMMB, virus inactivation by dimer DMMB, Met-Hb formation by monomer DMMB and Met-Hb formation by dimer DMMB). Methylene blue (MB) is known to produce not only singlet oxygen but also other ROS. 13,14) Therefore, DMMB, which is a derivative of MB, may also produce ROS other than singlet oxygen. In order to clarify which ROS are involved in virus inactivation and Met-Hb formation by activated monomer or dimer DMMB, the extent of the inactivation and formation in the presence or absence of ROS scavengers, quenchers or enhancer was evaluated. MATERIALS AND METHODSVirus Assays Bacteriophage R17 and its host, Escherichia coli Hfr C, were obtained from David Cook (Cerus Corporation, Concord, CA, U.S.A.). The plaque assay for bacteriophage R17 ...

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“…[4] When administered in high concentrations, the antioxidant effect of vanillin also is sufficient to prevent oxidative damage in mammalian cells. [5] The vanillyl acid moiety is also present in ligands of the vanilloid receptor, or transient receptor potential cation channel, subfamily V, member 1 (TRPV1), namely in capsaicin, gingerol, and shogaol. Capsaicin (Figure 1b) is the most prevalent member of the capsaicinoid family, and is the active component in chilli peppers, responsible for their characteristic spiciness.…”

Section: Introductionmentioning

confidence: 99%

Ortho-Methoxy Group as a Mild Inhibitor of the Reactions Between Carboxylic Acid and Phenols

et al. 2017

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According to the current database of natural products, over 25,000 compounds contain a vanillyl ring in their structure. The reasoning behind the high occurrence of the vanillyl ring structure seemed to be poorly understood, specifically the preference for a methoxy-substituted phenol structure as opposed to its dihydroxy analogue. To better understand this, we investigated the reaction mechanisms of two methoxyphenol structures, in syn and anti conformations, two hydroxyphenol structures, also in syn and anti conformations, and phenol as a reference structure, with acetic acid. Of the starting structures, the syn hydroxyphenol was found to be kinetically the most reactive, and formed the most stable product, while both hydroxyl-substituted phenols reacted more favorably with acetic acid than the methoxyphenols. A preference for the methoxyphenol molecule may exist as a way to hinder the formation of stable covalent bonds between natural products and cellular components.

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Cited by 98 publications

References 32 publications

Phytochemical uptake following human consumption of Montmorency tart cherry (L. Prunus cerasus) and influence of phenolic acids on vascular smooth muscle cells in vitro

Phytochemical uptake following human consumption of Montmorency tart cherry (L. Prunus cerasus) and influence of phenolic acids on vascular smooth muscle cells in vitro

Involvement of Reactive Oxygen Species in Hemoglobin Oxidation and Virus Inactivation by 1,9-Dimethylmethylene Blue Phototreatment.

Ortho-Methoxy Group as a Mild Inhibitor of the Reactions Between Carboxylic Acid and Phenols

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