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Fassnacht, D.; Rössing, Sabine; Stange, Jan; Pörtner, Ralf

doi:10.1023/a:1008895207570

Cited by 24 publications

(1 citation statement)

References 6 publications

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“…Numerous studies have reported near tissue densities of >10 8 cells/ml [41,44]]. These high densities in turn lead to increased production and concentration of products and enhance the specific productivity in a relatively small bioreactor [45–47]. However, HFBR systems are associated with large diffusional gradients that limit scale‐up and affect product quality.…”

Section: Filtration Systemsmentioning

confidence: 99%

Bioreactor systems for the production of biopharmaceuticals from animal cells

Warnock

Al‐Rubeai

2006

Biotech and App Biochem

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The demand for biopharmaceutical products is set to see a significant increase over the next few years. As a consequence, the processes used to produce these products must be able to meet market requirements. The present paper reviews the current technologies available for animal cell culture and highlights the advantages and disadvantages of each method, while also providing details of recent case studies. Processes are described for both suspension and anchorage-dependent cell lines.

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Section: Filtration Systemsmentioning

confidence: 99%

Bioreactor systems for the production of biopharmaceuticals from animal cells

Warnock

Al‐Rubeai

2006

Biotech and App Biochem

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Biotechnology

Becker¹,

Breithaupt²,

Doelle³

et al. 2007

Ullmann's Encyclopedia of Industrial Chemistry

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Biotechnology, 6. Special Applications

Doelle

Fiechter

Griensven³

et al. 2009

Ullmann's Encyclopedia of Industrial Chemistry

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The article contains sections titled: 1. Mammalian Cell Culture Technology 1.1. Introduction 1.2. Products from Mammalian Cells 1.3. Cell Types 1.4. Growth Medium for Cell Culture 1.5. Small‐Scale Culture Systems for Routine Use 1.6. Types of Bioreactors 1.7. Process Strategies 1.8. Downstream Processes 1.9. Regulatory and Safety Issues 2. Tissue Engineering 2.1. Application of Tissue Engineering 2.2. Principle of Tissue Engineering 2.3. Strategies 2.4. The Essentials 2.5. Cells 2.6. Biomatrices 2.7. Bioreactors for Tissue Engineering 2.8. Growing New from Old 3. Biotechnology and Food 3.1. Production of Food Additives by Cell Culture Systems 3.1.1. Amino Acids 3.1.2. Organic Acids 3.1.3. Vitamins 3.1.4. Sweet Compounds 3.1.5. Sugar Alcohols 3.1.6. Microbial Saccharides 3.1.7. Conjugated Linoleic Acids (CLA) 3.1.8. Lactulose 3.2. Enzyme‐Catalyzed Processes 3.2.1. Starch‐Modifying Enzymes 3.2.2. Lipases 3.2.3. Pectin‐Degrading Enzymes 3.2.4. Chymosin (Aspartic Protease) 4. Biotechnology and Health 4.1. Individualized Medicine 4.2. Clinical Diagnosis as Indicated in Genetic Anomalies in Cancer 4.3. Pharmaceutical Development 4.4. Define Molecular Mechanisms of Toxicity 4.5. Detection of Genetically Modified Organisms

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Untitled

Cited by 24 publications

References 6 publications

Bioreactor systems for the production of biopharmaceuticals from animal cells

Bioreactor systems for the production of biopharmaceuticals from animal cells

Biotechnology

Biotechnology, 6. Special Applications

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