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Optimization of the Composition and Technology of Diazoline Tablets

“…The drug action upon administration develops very slowly, which is related to a poor solubility of the parent substance in water [5]. Occurring in the gastrointestinal tract (GIT), dragee exhibits disintegration with simultaneous dissolution of the components, absorption of the parent compound, and its transfer to the blood.…”

“…The solubility of parent substances can be increased using various methods, including (i) additional grinding that results in a decrease of the particle size or an increase in the specific area and is frequently accompanied by amorphization of the powder and polymorphic transitions in the grains [6], (ii) distribution of the drug in a carrier matrix that stabilizes the dispersed state of the parent substance [7], (iii) mechanical mixing of drugs with high-molecular-mass compounds (polymers) capable of increasing the rate and degree of drug dissolution due the solubilizing action of the polymer [6], (iv) mechanical dispersion of a powdered drug and a polymer carrier that is accompanied by intense plastic straining of the drug particles and their incorporation into the polymer matrix [8]; and (v) introduction of special agents into the drug composition, which directly or indirectly influence the solubility of drugs [5].…”

Determination of organic impurities in pharmaceutical preparations

“…Normal-phase HPLC is very rarely used for the determination of organic impurities in pharmaceutical preparations [46][47][48][49][50][51][52][53][54][55][56][57][58][59][60], because their components and impurities are commonly polar compounds. In the majority of cases, unmodified silica gel [56,[58][59][60] and silica gel with modifying amino groups [57] are used as polar sorbents for the determination of impurities by normal-phase HPLC.…”

“…In the majority of cases, unmodified silica gel [56,[58][59][60] and silica gel with modifying amino groups [57] are used as polar sorbents for the determination of impurities by normal-phase HPLC. Nonpolar organic solvents with the addition of polar modifiers, e.g., CHCl 3 -methanolwater (4893 : 10 : 7) [58], ethanol-hexane (7 : 3) [56], hexane-ether [60], etc., are used as the mobile phase.…”