Abstract:Stressed degradation study of Drospirenone in H 2 O 2 and characterization of degradants by IR, NMR, LC-MS was done. Stressed degradation study of Drospirenone in H 2 O 2 and characterization of degradants by IR, NMR, and LC-MS was done. To evaluate the stability of Drospirenone under stress conditions, it was subjected to oxidative degradation, according to ICH guideline Q1A (R2). The analysis was carried out on C18 Thermo Hypersil BDS (250 × 4.6 × 5 mm) column, using ammonium acetate: acetonitrile (70:30) pH… Show more
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