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Abstract

pharmacological activities in vitro and in vivo and are part of the plant chemical defense mechanism. 38 Flavone polymethoxy has an influence on biochemical processes and plant physiology, has activities as antioxidants, enzyme inhibitors, anti-allergic, anticarcinogenic, antiviral, antiproliferative, and antiinflammatory. Sinensetin is a very important polymethoxy and bioactive product with various biological activities such as reduces pain, anticancer, antifungal, antitumor and antibacterial. 39 Eupatorin has pharmacological activity inducing apoptosis, vasodilators, antiinflammation, inhibitor P450, and antineoplastic. 40 Rosmarinic acid was isolated from many species of Lamiaceae and Boraginaceae and identified as one of the active components of several medicinal plants. 41 In 1958 Scarpati and Oriente began to isolate rosmarinic acid from Rosmarinus officinalis (Lamiaceae). Rosmarinic acid has various biological activities that make it an attractive material for the pharmaceutical, food, and cosmetics industries. Rosmarinic acid pharmacological activities tested in vitro are antioxidant, anti-inflammatory, antimutagenic, antigenotoxic, cytotoxic, and antimetastatic antiangiogenic, antimicrobial, and immunomodulatory. 42 Qualitative Analysis of Compounds in Orthosiphon aristatus (Blume) MiqQualitative of the Orthosiphon stamineus with UHPLC -ESI-QTOF-MS detected 61 compounds, 52 chemical structures can be identified to provide reference data for efficient separation and the idea of identifying secondary metabolites in other plants of the same genus. The compounds are six diterpenes, 26 phenolic acids, five tanshinones, four fatty acids and 11 flavonoids. Among these compounds, the sinensetin, rosmarinic acid, danshensu, caffeic acid and eupatorin are the main secondary metabolites. 43 Rosmarinic acid and sinensetin which are the main componen of O. aristatus have potential as antiviral agent. 43 The O. aristatus are divided into three varieties, namely white, white-purple and purple, based on the flower colour (Figure 1). 44 While nine compounds that have been successfully separated but have not been successfully identified, further studies are needed by comparing spectrum data and fragmentation patterns with literature. Guo and the team (2019) also reported compounds that have never been published in previous research or reviews. 26,37,44,45 The newly