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Abstract

Microalgae biomass has been recognized to have great potential as a source of novel bioactive compounds with industrial as well as health promoting applications in human, animal and aquatic lives. Microalgae have been gaining attention continuously due to its bioactive compounds. These bioactive compounds are primary and secondary metabolites produced by microalgae in order to adopt adverse environmental conditions. The simple growth requirement, higher mass productivity in short harvesting time making microalgae promising over other natural source of bioactive compounds. Several species of microalgae have undergone various screenings to identify and tap into these valuable resources, among them are the Isochrysis galbana, a brown microalgae belonging the class haptophyta. It is widely used as a feed for marine organism in aquaculture because of its high lipid content. Recently it is found Isochrysis galbana also exhibited the potential of being a source of high-value compounds with distinct biological activities including antitumor, antibacterial, antioxidant properties, antiinflammatory and hypochloesteromic. These activities have a wide range of applications in various industries that have not been broadly explored and fully exploited. The aim of this review paper is to update previous researches on the biological activity of Isochrysis galbana and to explore it as a pharmaceutical agent. INTRODUCTION: Nowadays, there is a huge interest among consumers and food industry on products that can promote good health, improve the state of wellbeing and decreases the risk of diseases 1, 2. Over the last few decades many microalgae has attracted the interest of researchers due to its high nutritional value and vast variety of novel metabolites that can be used in bioremediation 3 , biofuel 4 , biofertilizer 5 , human food 6 , animal feed 6 , and pharmaceutical industry 7 .

Phycoprospecting the nutraceutical potential of Isochrysis sp as a source of aquafeed and other high‐value products

“…Considerable inhibition against bacterial strains like E. coli, Streptococcus aureus, Streptococcus facelis and Salmonella typhii by Isochrysis sp. has also been reported in previous studies (Mishra & Mishra, 2018). Since most of Aeromonas species like A. bestiarum, A. salmonicida, A. schubertii, A. allosaccharophila, A. hydrophila and A. kandari have been known to infect freshwater fishes like Oreochromis niloticus (nile tilapia), they contribute as one of the major challenges in maintaining aquaculture health causing skin haemorrhage, enteritis and enlargement of gall bladder and liver (Baron et al, 2017;Saikot et al, 2013).…”

Insights into Co-Cultivation of Photosynthetic Microorganisms for Novel Molecule Discovery and Enhanced Production of Specialized Metabolites

“…Remarkably, the extremophilic microalgae, Isochrysis galbana, have been the subject of extensive research for their potential to produce lipids and biomass [92,93]. They have also been shown to be a food enrichment ingredient [94], degrade phenol, promote environmental restoration [95], and produce antioxidant compounds [96] and other molecules of pharmaceutical interest [97,98]. Additionally, promising antimicrobial activity has been shown by the secondary metabolites of I. galbana against pathogenic bacteria such as Listeria monocytogenes, S. aureus, B. subtilis, E. coli, S. epidermidis, Enterococcus faecalis, P. aeruginosa, and fungi from the Candida genus [99,100].…”