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Abstract

The solubility of Pranlukast in isopropanol and isopropanol-N,Ndimethylformamide binary solvents from 293.15 to 333.15 K at atmospheric pressure was determined by dynamic laser method. The results obtained show that the solubility of Pranlukast increased with increasing temperature in a certain solvent system, and also increased with increasing mole fraction of N,Ndimethylformamide in the binary solvent systems at a specific temperature. Experimental data were correlated using the modified Apelblat model, the CNIBS/Redlich-Kister model and the 3D Jouyban-Acree model. The results obtained suggest that all the models provided good fit, with the most accurate prediction obtained from the modified Apelblat model. Thermodynamic properties including standard enthalpy, standard entropy and molar Gibbs free energy change of solution were calculated as well, which indicated that the dissolution process was endothermic and non-spontaneous.