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Masso-Welch, Patricia A.; Darcy, Kathleen M.; Stangle-Castor, Nannette C.; Ip, Margot M.

doi:10.1023/a:1026491221687

Cited by 124 publications

(53 citation statements)

References 72 publications

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“…The development of the lobular epithelium during pregnancy is closely associated with the development of its supporting capillary plexus (Yasugi et al, 1989; Matsumoto et al, 1992b; Abdul Awal et al, 1996; Masso-Welch et al, 2000; Djonov et al, 2001). Because some lobular development occurs with each estrous cycle in the mammary gland of the nonpregnant rat (Schedin et al, 2000; Masso-Welch et al, 2000), we examined the frequency of capillaries associated with the immature terminal ductal lobular unit.…”

Section: Resultsmentioning

confidence: 99%

“…The mammary gland is composed of epithelium embedded in a stromal matrix containing fibroblasts, adipocytes, blood vessels, and lymphatics, as well as a variety of infiltrating leukocytes (reviewed in Howard and Gusterson, 2000; Richert et al, 2000; Masso-Welch et al, 2000). The importance of the local stromal environment on mammary epithelial proliferation, morphogenesis, hormone responsiveness, and functional differentiation has been well documented both in vivo (Kratochwil, 1969; Saka-kura et al, 1976, 1979; Haslam and Counterman, 1991; Cunha et al, 1992), and in co-culture experiments with fibroblasts (Lasfargues, 1957; Taylor-Papadimitriou et al, 1977; Visser et al, 1981; McGrath, 1983; Enami et al, 1983; Levine and Stockdale, 1985; Haslam, 1986; Reichmann et al, 1989; Taga et al, 1989; Strange et al, 1991; Kanazawa and Hosick, 1992; Sasaki et al, 1994; Soriano et al, 1995; Andersen, 1996) and adipocytes (Bartley et al, 1981; Levine and Stockdale, 1984; Beck and Hosick, 1988; Hovey et al, 1998; Zangani et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

“…Infiltrating leukocytes such as mast cells, eosinophils, and macrophages have been shown to contribute to the hormone-dependent remodeling of the mammary gland that occurs during pubertal development, lactogenesis, and involution, and are suggested to be involved in estrous cycle remodeling (Cole, 1933; Gouon-Evans et al, 2000; Lilla and Werb, 2010). Estrous cycle remodeling involves not only changes in the mammary epithelium, but alterations in the supporting vasculature, resulting in the development and subsequent regression of the extensive capillary plexus associated with each developing lobule (Soemarwoto and Bern, 1958; Yasugi et al, 1989; Matsumoto et al, 1992b; Abdul Awal et al, 1996; Masso-Welch et al, 2000; Djonov et al, 2001). The importance of mesenchymal/parenchymal interactions for hormone-dependent angiogenesis is supported by the observation that the development of mammary capillary plexuses in response to estrogen and progesterone stimulation does not occur in epithelium-cleared glands (Soemarwoto and Bern, 1958).…”

Section: Introductionmentioning

confidence: 99%

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Alterations in mast cell frequency and relationship to angiogenesis in the rat mammary gland during windows of physiologic tissue remodeling

Ramirez

Lee

Schedin

et al. 2012

Developmental Dynamics

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Background The mammary epithelium undergoes proliferation and regression accompanied by remodeling of the fibrocellular and vascular stroma. Mast cells are abundant in these compartments and have been implicated in remodeling during wound healing and cancer progression. The purpose of this study was to test the hypothesis that mast cell abundance correlates with physiologic mammary tissue remodeling during estrous cycling, lactogenesis (pregnancy and lactation) and involution. Results Mast cell and capillary frequency were quantified in the stroma surrounding ducts and lobules from mammary glands of rats. During estrous cycling, periductal mast cell numbers were unchanged, but lobule-associated mast cells significantly increased in the regressive phase of diestrus II. During lactogenesis, lobular stroma mast cells peaked early in pregnancy, at D2, followed by a significant decrease throughout lactation. Involution was associated with a rapid return in mast cell numbers, similar to diestrus II. Lobular vascularization peaked during the state of metestrus, when limited secretory differentiation occurs. Lobular angiogenesis peaked at D7 of pregnancy, regressed, and then returned to high levels during lactation and early involution, when secretory differentiation is high. Conclusions These results suggest mast cells are predominantly associated with regressive lobular remodeling during cycling and involution, whereas angiogenesis is predominantly associated with secretory differentiation.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Alterations in mast cell frequency and relationship to angiogenesis in the rat mammary gland during windows of physiologic tissue remodeling

Ramirez

Lee

Schedin

et al. 2012

Developmental Dynamics

Self Cite

View full text Add to dashboard Cite

show abstract

“…It is also present in a rudimentary and nonfunctional form in males. The mammary gland is a unique and dynamic organ that undergoes epithelial expansion and invasion during puberty and cycles of branching and lobular morphogenesis, secretory differentiation, and regression during pregnancy, lactation, and involution [1]. Embryonically, the mammary gland is derived from the ectoderm.…”

Section: Introductionmentioning

confidence: 99%

Aquaporin Water Channels in the Mammary Gland: From Physiology to Pathophysiology and Neoplasia

Mobasheri

Barrett‐Jolley

2013

J Mammary Gland Biol Neoplasia

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Aquaporins are membrane proteins that play fundamental roles in water and small solute transport across epithelial and endothelial barriers. Recent studies suggest that several aquaporin proteins are present in the mammary gland. Immunohistochemical techniques have confirmed the presence of aquaporin 1 (AQP1) and AQP3 water channels in rat, mouse, bovine and human mammary glands. Studies suggest that in addition to AQP1 and AQP3 AQP4, AQP5 and AQP7 proteins are expressed in different locations in the mammary gland. Aquaporins play key roles in tumor biology and are involved in cell growth, migration and formation of ascites via increased water permeability of micro-vessels. Emerging evidence suggests that expression of these proteins is altered in mammary tumors and in breast cancer cell lines although it is not yet clear whether this is a cause or a consequence of neoplastic development. This review analyzes the expression and potential functional roles of aquaporin water channels in the mammary gland. The physiological mechanisms involved in the transport of water and small solutes across mammary endothelial and epithelial barriers are discussed in the context of milk production and lactation. This paper also reviews papers from the recent cancer literature that implicate aquaporins in mammary neoplasia.

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“…In the mammary gland, each regenerative cycle occurs as a biphasic sequence of proliferation and apoptosis (Hovey et al, 2002) in which a small portion of the previous lobular structure persists (Masso-Welch et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

Positive and negative regulation of ΔN-p63 promoter activity by p53 and ΔN-p63-α contributes to differential regulation of p53 target genes

et al. 2003

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Mammary epithelial regeneration implies the existence of cellular progenitors with retained replicative capacity, prolonged lifespan and developmental potency. Evidence exists that DN-p63 isoforms preserve these features by modulating p53 activity in basal epithelia. DN-p63 mRNA levels decline at the onset of differentiation suggesting that its transcriptional regulation may contribute to the initiation of differentiation. To study transcriptional regulation of DN-p63, a 10.3 kbp fragment containing the DN-p63 promoter was isolated. We report here that DN-p63 is a positive and negative transcriptional target of p53 and DN-p63-a, respectively. Disruption of p53 activity or expression abolishes the expression of DN-p63-a. This regulation is mediated by a p53-binding element sufficient to confer these activities to a heterologous promoter. Chromatin immune-precipitation indicates that, in asynchronously growing cells, p53 occupies this element. In response to DNA damage, DN-p63-a is recruited to this element as transcription of DN-p63 declines. Disruption of DN-p63-a expression had differential effects on the transcriptional regulation of several p53-target genes. These findings indicate that p53 contributes to the preservation of basal epithelia by driving the expression of DN-p63 isoforms. These studies also suggest that in response to genotoxic stress, DN-p63-a mediates the silencing of its own promoter thereby altering the pattern of p53-target gene expression.

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Untitled

Cited by 124 publications

References 72 publications

Alterations in mast cell frequency and relationship to angiogenesis in the rat mammary gland during windows of physiologic tissue remodeling

Alterations in mast cell frequency and relationship to angiogenesis in the rat mammary gland during windows of physiologic tissue remodeling

Aquaporin Water Channels in the Mammary Gland: From Physiology to Pathophysiology and Neoplasia

Positive and negative regulation of ΔN-p63 promoter activity by p53 and ΔN-p63-α contributes to differential regulation of p53 target genes

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