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Goodacre, Royston

doi:10.1186/gb-2005-6-11-354

Cited by 17 publications

(9 citation statements)

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“…Metabolomics is a powerful approach to screen for physiological responses to diet, drugs and disease [14]. This analysis detects small molecule metabolites in blood or tissues.…”

Section: Introductionmentioning

confidence: 99%

Untargeted Metabolomic Screen Reveals Changes in Human Plasma Metabolite Profiles Following Consumption of Fresh Broccoli Sprouts

Housley

Magaña

Hsu

et al. 2018

Molecular Nutrition Food Res

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“…Metabolomics is a powerful approach to screen for physiological responses to diet, drugs and disease [14]. This analysis detects small molecule metabolites in blood or tissues.…”

Section: Introductionmentioning

confidence: 99%

Untargeted Metabolomic Screen Reveals Changes in Human Plasma Metabolite Profiles Following Consumption of Fresh Broccoli Sprouts

Housley

Magaña

Hsu

et al. 2018

Molecular Nutrition Food Res

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“…Metabolomic signal processing consists of several steps: processing of raw data that allows for comparisons of different data sets, data mining that involves use of statistical tools for high-throughput analysis which identifies variables of interest, and quantitative measurements that provide both absolute and relative concentrations of selected metabolites which contribute mostly to the pathology investigated (Glassbrook et al 2000; Dunn et al 2005; Goodacre 2005). Herein, we describe some signal-processing algorithms used in metabolomics and 1 H-MRS.…”

Section: Metabolomics Signal Processingmentioning

confidence: 99%

“…The response to treatment is also qualitative. Therefore, during the past decade, the search for diagnostic biomarkers of specific disorders has escalated and has included genomics, proteomics, and, most recently, metabolomics analysis of a variety of disease states (Fiehn et al 2001; German et al 2005; Goodacre 2005; Hollywood et al 2006). …”

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confidence: 99%

Metabolomics of Neural Progenitor Cells: A Novel Approach to Biomarker Discovery

Maletić-Savatić

Vingara

Manganas

et al. 2008

Cold Spring Harbor Symposia on Quantitative Biology

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Finding biomarkers of human neurological diseases is one of the most pressing goals of modern medicine. Most neurological disorders are recognized too late because of the lack of biomarkers that can identify early pathological processes in the living brain. Late diagnosis leads to late therapy and poor prognosis. Therefore, during the past decade, a major endeavor of clinical investigations in neurology has been the search for diagnostic and prognostic biomarkers of brain disease. Recently, a new field of metabolomics has emerged, aiming to investigate metabolites within the cell/tissue/organism as possible biomarkers. Similarly to other “omics” fields, metabolomics offers substantial information about the status of the organism at a given time point. However, metabolomics also provides functional insight into the biochemical status of a tissue, which results from the environmental effects on its genome background. Recently, we have adopted metabolomics techniques to develop an approach that combines both in vitro analysis of cellular samples and in vivo analysis of the mammalian brain. Using proton magnetic resonance spectroscopy, we have discovered a metabolic biomarker of neural stem/progenitor cells (NPCs) that allows the analysis of these cells in the live human brain. We have developed signal-processing algorithms that can detect metabolites present at very low concentration in the live human brain and can indicate possible pathways impaired in specific diseases. Herein, we present our strategy for both cellular and systems metabolomics, based on an integrative processing of the spectroscopy data that uses analytical tools from both metabolomic and spectroscopy fields. As an example of biomarker discovery using our approach, we present new data and discuss our previous findings on the NPC biomarker. Our studies link systems and cellular neuroscience through the functions of specific metabolites. Therefore, they provide a functional insight into the brain, which might eventually lead to discoveries of clinically useful biomarkers of the disease.

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“…Modifications to metabolic pathways can be investigated using metabolomic analysis, an emerging technique that can be used to identify metabolic biomarkers via the analysis of individual metabolites present in an organic sample. The “metabolome” refers to all metabolites of biological origin below 1500 daltons (i.e., a low molecular weight) [ 6 ], and provides insight into physiological or pathological mechanisms at a given time. A specific feature of the metabolome is that it is dynamic and subject to the influence of environmental factors, such as diet, toxins, and disease [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Metabolomic Studies in Inner Ear Pathologies

et al. 2022

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Sensorineural hearing loss is the most common sensory deficit. The etiologies of sensorineural hearing loss have been described and can be congenital or acquired. For congenital non-syndromic hearing loss, mutations that are related to sites of cochlear damage have been discovered (e.g., connexin proteins, mitochondrial genes, etc.). For cytomegalovirus infection or auditory neuropathies, mechanisms are also well known and well researched. Although the etiologies of sensorineural hearing loss may be evident for some patients, the damaged sites and pathological mechanisms remain unclear for patients with progressive post-lingual hearing loss. Metabolomics is an emerging technique in which all metabolites present in a sample at a given time are analyzed, reflecting a physiological state. The objective of this study was to review the literature on the use of metabolomics in hearing loss. The findings of this review suggest that metabolomic studies may help to develop objective tests for diagnosis and personalized treatment.

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Abstract: A report on the First Annual Meeting of the Metabolomics Society, Tsuruoka, Japan, 20-23 June 2005.

Cited by 17 publications

References 0 publications

Untargeted Metabolomic Screen Reveals Changes in Human Plasma Metabolite Profiles Following Consumption of Fresh Broccoli Sprouts

Untargeted Metabolomic Screen Reveals Changes in Human Plasma Metabolite Profiles Following Consumption of Fresh Broccoli Sprouts

Metabolomics of Neural Progenitor Cells: A Novel Approach to Biomarker Discovery

Metabolomic Studies in Inner Ear Pathologies

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