Untitled

Ling, Pei-Ra; Khaodhiar, Lalita; Bistrian, Bruce R.; Keane-Ellison, Mary; Thibault, Ann; Tawa, Nicholas E.

doi:10.1023/a:1012388206553

Cited by 26 publications

(4 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…PN-dependent patients are at risk for bone disease owing to continued exposure to aluminum in PN, low serum 25(OH) vitamin D (25(OH)D) (6, 7) and insulin-like growth factor (IGF)-1 and/or IGF-binding protein-3 (IGF-BP3) concentrations, and chronic inflammation (7, 8). To our knowledge, there is only one published study that systematically examined bone mineral density (BMD) of infants and children with PN-dependent IF.…”

Section: Introductionmentioning

confidence: 99%

Bone Deficits in Parenteral Nutrition–Dependent Infants and Children With Intestinal Failure Are Attenuated When Accounting for Slower Growth

Appleman¹,

Kalkwarf

Dwivedi

et al. 2013

J. pediatr. gastroenterol. nutr.

View full text Add to dashboard Cite

Objective To determine if bone mineral content (BMC) and density (BMD) of infants and children with parenteral nutrition (PN)-dependent intestinal failure (IF) is lower than healthy controls, and investigate potential causes of lower BMC and BMD. Methods We performed a cross-sectional study comparing infants and children with PN-dependent IF with duos of age, sex, and race matched controls. Lumbar spine BMC and BMD were measured by dual energy x-ray absorptiometry, and serum cytokines, aluminum, IGF-1, insulin-like growth factor-binding protein (IGF-BP)-3, parathyroid hormone, 25(OH) vitamin D, and 1,25(OH)2 vitamin D were measured. Generalized estimating equation models accounting for matching were used for comparisons. Results BMC was 15% and BMD was 12% lower in IF participants than controls (p≤0.004). Group differences were attenuated to 3% and 7% and were not statistically significant (p=0.40 and p=0.07) when adjusted for length and weight; length- and weight-for-age were lower in IF than control participants (12.5% vs. 63%; 29.5% vs. 54%, p≤0.03). IF participants had higher serum aluminum (23 vs. 7 mcg/L, p<0.0001), IGF-1 (97 vs. 64 ng/mL, p=0.04), and 25(OH) vitamin D concentrations (40 vs. 30 ng/mL, p=0.0005), and lower IGF-BP3 (1418 vs. 1812 ng/mL, p<0.0001) and parathyroid hormone concentrations (51 vs. 98 pg/mL, p=0.0002) than controls. There was no difference in serum cytokine concentrations (p≥0.09). Conclusions Growth retardation is a significant problem for PN-dependent IF patients. Additional investigation is needed to elucidate the cause and its impact on bone mass and density, especially the role of IGF-1 resistance and aluminum toxicity.

show abstract

Section: Introductionmentioning

confidence: 99%

Bone Deficits in Parenteral Nutrition–Dependent Infants and Children With Intestinal Failure Are Attenuated When Accounting for Slower Growth

Appleman¹,

Kalkwarf

Dwivedi

et al. 2013

J. pediatr. gastroenterol. nutr.

View full text Add to dashboard Cite

show abstract

“…We have previously published the findings that IL-6 and sTNF receptor- II in urine and serum and TNFα in urine are elevated in a larger cohort of HPN patients compared with controls [18]. At that time, arachidonic acid in serum phospholipids and triglycerides was substantially elevated, and relative conversion from linoleic acid was similarly increased.…”

Section: Discussionmentioning

confidence: 99%

“…In our HPN patients, we have documented elevations in sensitive markers of inflammation [soluble tumor necrosis factor (TNF) receptor and interleukin-6 (IL-6)] [4], although not to the levels seen in obvious inflammatory states. Others have shown that the proportion of fat energy in HPN predicts the future development of PN-associated liver dysfunction [5,6].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effect of a Fish Oil–Containing Beverage on Changes in Plasma Lipid Fatty Acids in Patients With Malabsorption

et al. 2010

Self Cite

View full text Add to dashboard Cite

Background The aim of this pilot study was to assess tolerance of a beverage containing ω-3 fatty acids (fish oil) in patients with malabsorption receiving chronic parenteral nutrition (PN). We wanted to determine whether fish oil could be absorbed and incorporated into plasma fatty acids, and reduce markers of inflammation. Methods This was a small intervention study in home-dwelling PN-dependent patients with chronic malabsorption. Ten patients were provided a drink containing 1.5g of fish oil per day for 12 weeks. Baseline and post-supplement serum fatty acid profiles were compared. Results Five of 10 patients withdrew from the study due to gastrointestinal side effects, principally worsened diarrhea, associated with the supplement. Modest increases were found in 20:5ω-3, 22:5ω-3, and 22:6ω-3 levels in both phospholipids and triglycerides in plasma (all p<0.05). In phospholipids, a reduced arachidonic acid level was seen (p=0.02). These changes were not sufficient to effect improvements in serum tumor necrosis factor-alpha (TNFα), soluble TNF receptor, c-reactive protein or Interleukin-6. Conclusions Some patients with severe malabsorption can absorb oral ω-3 fatty acid supplements and can incorporate these fatty acids into serum phospholipids and triglycerides. However, side effects are very common, and no anti-inflammatory effect was found, presumably related to the modest level of fatty acid change.

show abstract

Treatment of Cachexia in the Elderly

Yeh

Schuster

Cachexia and Wasting: A Modern Approach

View full text Add to dashboard Cite

Untitled

Cited by 26 publications

References 27 publications

Bone Deficits in Parenteral Nutrition–Dependent Infants and Children With Intestinal Failure Are Attenuated When Accounting for Slower Growth

Bone Deficits in Parenteral Nutrition–Dependent Infants and Children With Intestinal Failure Are Attenuated When Accounting for Slower Growth

Effect of a Fish Oil–Containing Beverage on Changes in Plasma Lipid Fatty Acids in Patients With Malabsorption

Treatment of Cachexia in the Elderly

Contact Info

Product

Resources

About