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Abstract

A novel phenolic compound, artocarpol A (1), was isolated from the root bark of Artocarpus rigida and its structure determined by spectroscopic methods and by comparison with its diacetate derivative. Compound 1 strongly inhibited superoxide formation in phorbol 12-myristate 13-acetate (PMA) stimulated rat neutrophils in a concentration-dependent manner with an IC 50 value of 13.7 AE 0.7 mm. Compound 1 also showed a significant inhibitory effect on tumor necrosis factor-a (TNF-a) formation in lipopolysaccharide(LPS)-stimulated RAW 264.7 cells.

Cytotoxic and NF-κB Inhibitory Constituents of Artocarpus rigida

“…The UV (λ max 234, 340, and 360 nm) and IR (ν max 3364, 1615, 1456 cm −1 ) spectra showed absorption characteristics of a stilbenoid derivative 15–19. The molecular formula of C 19 H 16 O 4 was determined by HRESIMS, and was consistent with a 14-carbon stilbene nucleus bearing a prenyl group substituent.…”

Natural Products Bearing a Bicyclo[3.2.0]Heptane Skeleton

“…Artocarpol A 39 was isolated from the root barks of Artocarpus rigida collected at Ping-Tung Hsien, Taiwan [25]. The alkaloid bicyclomahanimbicine 40 was isolated from M. koenigi leaves and may play a key role in the biosynthesis of this alkaloid in the plant [26].…”

Flavonoids from Artocarpus Lanceifolius

“…Species of genus Artocarpus have been shown to be rich in phenolic compounds [1][2][3][4][5][6][7][8][9][10][11][12][13] and terpenoids [14]. Three new isoprenylated flavones, artoindonesianins G-I, together with the two known flavones artelastofuran and artelasticin, have been isolated from the heartwood of Artocarpus lanceifolius which is native to Singapore, Indonesia and other Southeast countries [13].…”