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Konechnik, Thomas J.; Kos, Rosemary; White, Joe L.; Hem, Stanley L.; Borin, Marie T.

doi:10.1023/a:1015961700383

Cited by 10 publications

(1 citation statement)

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“…Several methods are presently used to reduce cholesterol levels. These include diet, exercise, ileal bypass or resection, nicotinic acid (commonly referred to as niacin), 3‐hydroxy‐3‐methylglutaryl‐CoA reductase inhibitors, such as lovastatin [4], and bile acid‐sequestering resins, such as cholestyramine [5] and colestipol [6,7].…”

Section: Introductionmentioning

confidence: 99%

Synthesis of cationic polysaccharide derivatives and their hypocholesterolaemic capacity

Lee¹,

Kim²,

Kim³

et al. 2002

Biotechnol. Appl. Biochem.

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High-capacity bile acid-sequestering biopolymers with cationic polysaccharide derivatives have been developed. Cholestyramine, the bile acid sequestrant most widely used for treating hypercholesterolaemia, has unpleasant side effects because of the hydrophobic nature of its backbone. Methylan, a high-viscosity polysaccharide produced by Methylobacterium organophilum, was selected as a model polysaccharide for derivatization. Methylan was aminated to add dialkylaminoalkyl and free amino groups at hydroxyl sites in the methylan backbone, and these derivatives were quaternized to produce pH-independent cationic polyelectrolytes. The in vitro bile acid-binding capacity of quaternized DEAE-methylan was approximately 50% higher than that of cholestyramine. The bile acid-binding capacity of methylan derivatives increased with the number of carbons in the alkyl groups, indicating that hydrophobic interaction is a secondary factor for the sequestration of bile acids.

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Section: Introductionmentioning

confidence: 99%