Untitled

Abstract

Drug release from fatty suppository bases containing a solid dispersion of diazepam with amylodextrin or a complex of prednisolone with amylodextrin was analyzed in a flow-through model. Being present as a suspension in the fatty base, particles of complex or solid dispersion are transported to the lipid-water interface by sedimentation. After entering the aqueous phase they partially dissolve. The suppositories showed increased drug release compared with the corresponding suppositories containing drug only. Because of the partial solubility of amylodextrin, drug release was lower than the release from drug-cyclodextrin complexes. Use of the soluble fraction of amylodextrin for both the solid dispersion and the complex further enhanced drug release, but it was still below that of drug-cyclodextrin complexes.

Sustainable carbon materials

“…The ''expansion'' of these compact (often semi-crystalline) polymers is therefore vital for the development of materials (e.g., sustainable porous carbons) that are suitable for applications where mass transport/diffusion (e.g., chromatography) and surface interactions (e.g., liquid phase catalysis) are critical to function. The work of Glenn et al and Te Wierik et al 330 in the 1990s demonstrated the preparation of starch-based xerogels (S BET o 145 m 2 g À1 ), based on a sol-gel-like process involving the thermal gelation and recrystallization (often to referred to as ''retrogradation'') of starch, followed by the careful replacement of pore entrapped H 2 O for a lower surface tension solvent (e.g., CH 3 CH 2 OH) and eventually air (e.g., via supercritical extraction). 116 In more recent publications this approach has been generalized to ''porous polysaccharides'' that is in principle applicable to the majority of polysaccharides (Fig.…”