Abstract:Chronic atrophic gastritis can be induced either by H. pylori or by an autoimmune process. The protein product of bcl-2, which is a protooncogene, blocks apoptosis. Aberrant bcl-2 expression has been found in 68% of atrophic gastritis patients. The aim of this study was to compare bcl-2 expression in 20 autoimmune atrophic gastritis patients to that in 20 H. pylori-associated atrophic gastritis patients. Twenty patients with H. pylori antral gastritis but without atrophy served as controls. The bcl-2 expressio… Show more
“…Gastrin has also been reported to increase the expression of bcl-2 and survivin in KATO III gastric adenocarcinoma cells (16). Increased immunohistochemical bcl-2 expression has been demonstrated in autoimmune as well as H. pylori associated atrophic gastritis (23) and in hypergastrinemia-associated ECL-cell gastric carcinoid tumors (1; 14). We also demonstrated increased bcl-2 expression in patients with atrophic gastritis and hypergastrinemia, but this bcl-2 expression appeared to occur predominantly in stromal and lymphoid cells rather than in ECL cells (figure 6).…”
Section: Discussionmentioning
confidence: 99%
“…IMGE-5) origin and gastrin-induced alterations in the expression of several members of the bcl-2 family of proteins have also previously been demonstrated (10; 11; 16; 31-33). Increased immunohistochemical expression of anti-apoptotic bcl-2 has also been demonstrated in biopsies obtained from human subjects with atrophic gastritis (23) and type I gastric carcinoid tumors (1).…”
“…Gastrin has also been reported to increase the expression of bcl-2 and survivin in KATO III gastric adenocarcinoma cells (16). Increased immunohistochemical bcl-2 expression has been demonstrated in autoimmune as well as H. pylori associated atrophic gastritis (23) and in hypergastrinemia-associated ECL-cell gastric carcinoid tumors (1; 14). We also demonstrated increased bcl-2 expression in patients with atrophic gastritis and hypergastrinemia, but this bcl-2 expression appeared to occur predominantly in stromal and lymphoid cells rather than in ECL cells (figure 6).…”
Section: Discussionmentioning
confidence: 99%
“…IMGE-5) origin and gastrin-induced alterations in the expression of several members of the bcl-2 family of proteins have also previously been demonstrated (10; 11; 16; 31-33). Increased immunohistochemical expression of anti-apoptotic bcl-2 has also been demonstrated in biopsies obtained from human subjects with atrophic gastritis (23) and type I gastric carcinoid tumors (1).…”
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