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Jang, Meishiang; Pezzuto, John M.

doi:10.1023/a:1009742504152

Cited by 29 publications

(15 citation statements)

References 9 publications

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“…The exact biochemical regulation of Cox-2 is not well understood, however it is thought that NF-␤ may play an important role. The nuclear transcription factor, NF-␤, is one of the most ubiquitous eukaryotic transcription factors, and has the ability to regulate gene expression involved in the proliferation and growth of cells, inflammation responses and many more biological processes, such as positive regulation of Cox-2 [34]. There is evidence to suggest that resveratrol can inhibit the activity of NF-␤ by attenuating IKK activity, a key regulator of NF-␤ activity [35].…”

Section: Discussionmentioning

confidence: 99%

Phytoalexin resveratrol attenuates the mutagenicity of the heterocyclic amines 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline

Boyce

Doehmer²,

Gooderham

2004

Journal of Chromatography B

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Section: Discussionmentioning

confidence: 99%

Phytoalexin resveratrol attenuates the mutagenicity of the heterocyclic amines 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline

Boyce

Doehmer²,

Gooderham

2004

Journal of Chromatography B

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“…Resveratrol can inhibit the hydroperoxidase function of COX which can lead to anti-initiation activity and can also inhibit the production of arachidonic acid metabolites catalyzed by COX-1 or COX-2, contributing to its antipromotion activity [97]. COX-1 and COX-2 are respectively constitutive and inducible enzymes that catalyze the production of pro-inflammatory prostaglandins (PGs) from arachidonic acid.…”

Section: C) Resveratrol Chemoprevention By Inhibition Of Lipid Mediatorsmentioning

confidence: 99%

“…For example, it has been shown that the increase in inducible NO synthase and in eNOS was correlated with tumoral growth and vascular invasion in human colorectal cancer [209]. Resveratrol inhibits the de novo formation of inducible nitric oxide synthase (iNOS) in mouse macrophages stimulated with lipopolysaccharide, without affecting COX-2 expression [97]. So, the polyphenol is able to inhibit NO generation in activated macrophages by reducing the amount of cytosolic iNOS protein and by inhibiting the activation of NFκB induced by LPS [210].…”

Section: A) Resveratrol Chemoprevention By Inhibition Of Nitric Oxidementioning

confidence: 99%

Resveratrol as a Chemopreventive Agent: A Promising Molecule for Fighting Cancer

Delmas¹,

Lançon²,

Colin³

et al. 2006

CDT

347

223

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“…The chemopreventive property of resveratrol proposed by Jang et al [12] was based on the inhibition of tumor initiation, promotion and progression. Analogs of resveratrol inhibit TNF-α induced activation of nuclear factor κB (NF-κB) [13].…”

Section: Introductionmentioning

confidence: 99%

In vitro and in vivo studies on stilbene analogs as potential treatment agents for colon cancer

Paul

Mizuno

Lee

et al. 2010

European Journal of Medicinal Chemistry

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Based on the potential of resveratrol as a colon cancer chemopreventive agent, a set of 26 stilbenes were synthesized and tested against the colon cancer cell lines HT-29 and Caco-2. (Z)-4-(3,5-dimethoxystyryl)aniline (4), (Z)-methyl 4-(3,5-dimethoxystyryl)benzoate (6), and (Z)-1,3-dimethoxy-5-(4-methoxystyryl)benzene (10) showed strong inhibitory activity in vitro. In vivo studies using HT-29 xenografts in immunodeficient mice were conducted with 4, 6 and 10, together with their corresponding trans isomers (3, 5, and 9, respectively), at the dose of 10 mg/kg body weight. Tumor volume was significantly lowered in 3-, 4-, and 9-treated groups. The cis-and trans-amino analogs (4 and 3, respectively) had similar effect on tumor growth, a 40% decrease compared to the control. Analysis of the serum revealed that 4 isomerized to 3, which may explain their similar effects in SCID mice. Stilbenes 5, 6, 9, and 10 retained their configurations in the serum. Stilbenes 6 and 10 lacked tumor suppressive effect in SCID mice; the serum levels of these analogs were low (18.8 and 15.5 ng/mL, respectively). Stilbene 9, while weakly active in vitro demonstrated good activity in vivo; 9 was found at higher levels in the serum (69.9 ng/mL) compared to 10. The anti-tumorigenic activity of these stilbene analogs may be partly linked to their effects on proteins involved in cell proliferation, as observed by lowered expression of proliferating cell nuclear antigen and upregulation of the cyclin dependent kinase inhibitor, p27, in the tumor tissues. Overall, identification of the anti-tumorigenic potential of these compounds provides opportunities for their use against colorectal cancer.

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Cited by 29 publications

References 9 publications

Phytoalexin resveratrol attenuates the mutagenicity of the heterocyclic amines 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline

Phytoalexin resveratrol attenuates the mutagenicity of the heterocyclic amines 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline

Resveratrol as a Chemopreventive Agent: A Promising Molecule for Fighting Cancer

In vitro and in vivo studies on stilbene analogs as potential treatment agents for colon cancer

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