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doi:10.1002/smll.v5:16

Cited by 7 publications

(2 citation statements)

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“…1 Nanocarriers (NCs) are of interest as therapeutic delivery agents, [2][3][4][5] as targeted imaging agents for diagnosis, 1,[6][7][8][9] and, in the dual role of therapy and diagnosis, as "theranostic" agents. [10][11][12][13][14][15] Most often, NCs for therapeutic applications are rendered fluorescent by postfunctionalizing the surface of the NC with a fluorescent dye. [16][17][18][19][20][21][22][23] The main concerns with this approach are that (1) far fewer agents can be incorporated on the surface versus in the interior before the onset of quenching and (2) the dyes may interfere with targeting ligands placed on the NC surface (ligands that are often present in relatively low amounts).…”

Section: Introductionmentioning

confidence: 99%

Formulation of long-wavelength indocyanine green nanocarriers

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Faenza²,

et al. 2017

J. Biomed. Opt

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Indocyanine green (ICG), a Food and Drug Administration (FDA)-approved fluorophore with excitation and emission wavelengths inside the "optical imaging window," has been incorporated into nanocarriers (NCs) to achieve enhanced circulation time, targeting, and real-time tracking in vivo. While previous studies transferred ICG exogenously into NCs, here, a one-step rapid precipitation process [flash nanoprecipitation (FNP)] creates ICG-loaded NCs with tunable, narrow size distributions from 30 to 180 nm. A hydrophobic ion pair of ICG-tetraoctylammonium or tetradodecylammonium chloride is formed either in situ during FNP or preformed then introduced into the FNP feed stream. The NCs are formulated with cores comprising either vitamin E (VE) or polystyrene (PS). ICG core loadings of 30 wt. % for VE and 10 wt. % for PS are achieved. However, due to a combination of molecular aggregation and Förster quenching, maximum fluorescence (FL) occurs at 10 wt. % core loading. The FL-per-particle scales with core diameter to the third power, showing that FNP enables uniform volume encapsulation. By varying the ICG counter-ion ratio, encapsulation efficiencies above 80% are achieved even in the absence of ion pairing, which rises to 100% with 1∶1 ion pairing. Finally, while ICG ion pairs are shown to be stable in buffer, they partition out of NC cores in under 30 min in the presence of physiological albumin concentrations.

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Section: Introductionmentioning

confidence: 99%

Formulation of long-wavelength indocyanine green nanocarriers

Pansare

Faenza²,

et al. 2017

J. Biomed. Opt

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“…[34] Manuel et al synthesized biocompatible, multimodal, theranostic functional iron oxide nanoparticles that exhibit excellent properties for targeted cancer therapy and both optical and magnetic resonance imaging. [35] Using a novel water-based method, they finished the encapsulation of both near-infrared dyes and anticancer drugs and realized successful theranostics. [36] In recent research, a novel method to synthesize Gd-NPs was reported wherein a Gd-based MR contrast agent self-assembled into gadolinium NPs under the action of furin proteins.…”

Section: Surface Modification With Organic Moleculesmentioning

confidence: 99%

Surface modification of magnetic nanoparticles in biomedicine

2015

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Progress in surface modification of magnetic nanoparticles (MNPs) is summarized with regard to organic molecules, macromolecules and inorganic materials. Many researchers are now devoted to synthesizing new types of multi-functional MNPs, which show great application potential in both diagnosis and treatment of disease. By employing an ever-greater variety of surface modification techniques, MNPs can satisfy more and more of the demands of medical practice in areas like magnetic resonance imaging (MRI), fluorescent marking, cell targeting, and drug delivery.

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Non-cytotoxic silver nanoparticle-polyvinyl alcohol hydrogels with anti-biofilm activity: designed as coatings for endotracheal tube materials

et al. 2014

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Endotracheal intubation is commonly associated with hospital-acquired infections as the intubation device acts as reservoir for bacterial colonization in the lungs. To reduce the incidence of bacterial colonization on the tubes, hydrogel coatings loaded with antimicrobial agents are gaining popularity. The aim of this study was to incorporate silver nanoparticles (AgNPs) into polyvinyl alcohol (PVA) to form stable hydrogels. Embedding AgNPs into PVA resulted in a decreased elongation at break and an increased tensile strength compared to PVA alone. The Ag release profile varied as a function of the degree of hydrolysis of PVA: the higher degree of hydrolysis demonstrated a lower release rate. Fourier infrared transform spectroscopy demonstrated that AgNPs interacted exclusively with the -OH groups of PVA. AgNP-loaded PVA was non-toxic against human normal bronchial epithelial cells while effective against the attachment of Pseudomonas aeruginosa and Staphylococcus aureus with a greater effect on P. aeruginosa.

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Cited by 7 publications

References 0 publications

Formulation of long-wavelength indocyanine green nanocarriers

Formulation of long-wavelength indocyanine green nanocarriers

Surface modification of magnetic nanoparticles in biomedicine

Non-cytotoxic silver nanoparticle-polyvinyl alcohol hydrogels with anti-biofilm activity: designed as coatings for endotracheal tube materials

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