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doi:10.1111/jdv.2019.33.issue-1

Acad Dermatol Venereol

2019

DOI: 10.1111/jdv.2019.33.issue-1

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Cited by 18 publications

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“…Notably, the aged skin commonly exhibits signs and symptoms of inflammation, such as pruritus and senile xerosis. [10][11][12] Because of its relatively large size, we hypothesized that the skin could be an important contributor to the elevated levels of circulating cytokines in chronologically aged humans, despite the fact that it typically displays little evidence of inflammation. Not only its size, but also its unique anatomic site, serving as the interface between the body and external environment, supports our hypothesis.…”

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<p>Could Inflammaging and Its Sequelae Be Prevented or Mitigated?</p>

Man

Elias

2019

CIA

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Aged humans display a chronic and low-grade inflammation, termed "inflammaging", which has been potentially linked to the subsequent development of some agingassociated systemic disorders, including type 2 diabetes, atherosclerotic cardiovascular disease, Alzheimer's disease and obesity. Though the origin of aging-associated systemic inflammation is uncertain, epidemiological studies show that inflammatory dermatoses (psoriasis and eczema) are risk factors for some aging-associated systemic disorders, such as type 2 diabetes and atherosclerotic cardiovascular disease. Moreover, recent studies demonstrate that epidermal dysfunction in aged skin not only causes cutaneous inflammation, but also a subsequent increase in circulating levels of proinflammatory cytokines, suggesting that the skin could be a major contributor to inflammaging. This hypothesis is further supported by reductions in circulating levels of proinflammatory cytokines in both aged humans and murine, following improvements in epidermal function with topical emollients. Therefore, correction of epidermal dysfunction could be a novel approach for the prevention and mitigation of certain inflammation-associated chronic disorders in aged humans.

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confidence: 99%

<p>Could Inflammaging and Its Sequelae Be Prevented or Mitigated?</p>

Man

Elias

2019

CIA

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Influence of “Not Relevant” Responses on the Dermatology Life Quality Index (DLQI) for Patients With Psoriasis in the United States

Barbieri

Gelfand

2019

JAMA Dermatol

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The Dermatology Life Quality Index (DLQI) is a popular healthrelated quality-of-life measure in dermatology. However, there are concerns that scoring "not relevant" responses as equivalent to "not at all" may bias the DLQI toward underestimating severity of disease, and recent studies of patients with psoriasis in Europe found that those who responded "not relevant" had more severe disease than those who responded "not at all." 1,2 Given cross-cultural differences in response patterns, the purpose of this study was to evaluate whether a similar association exists for the English-language DLQI administered to patients with psoriasis in the United States. 3 Methods | A cross-sectional reanalysis was conducted using data from the Dermatology Clinical Effectiveness Research Network. 4 For items 3 through 10 on the DLQI, overall subjective and objective evaluation of the severity of disease were compared between those who responded "not relevant" and those who responded "not at all." Subjective severity of disease was assessed using the DLQI, EuroQol Health-Related

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Localization, Morphologic Features, and Chemical Composition of Calciphylaxis-Related Skin Deposits in Patients With Calcific Uremic Arteriolopathy

et al. 2019

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; for the Groupe Angio-Dermatologie of the French Society of Dermatology IMPORTANCE Calcific uremic arteriolopathy (CUA), a rare, potentially fatal, disease with calcium deposits in skin, mostly affects patients with end-stage renal disease who are receiving dialysis. Chemical composition and structure of CUA calcifications have been poorly described. OBJECTIVES To describe the localization and morphologic features and determine the precise chemical composition of CUA-related calcium deposits in skin, and identify any mortality-associated factors. DESIGN, SETTING, AND PARTICIPANTS A retrospective, multicenter cohort study was conducted at 7 French hospitals including consecutive adults diagnosed with CUA between January 1, 2006, and January 1, 2017, confirmed according to Hayashi clinical and histologic criteria. Patients with normal renal function were excluded. For comparison, 5 skin samples from patients with arteriolosclerosis and 5 others from the negative margins of skin-carcinoma resection specimens were also analyzed. MAIN OUTCOMES AND MEASURES Localization and morphologic features of the CUA-related cutaneous calcium deposits were assessed with optical microscopy and field-emissionscanning electron microscopy, and the chemical compositions of those deposits were evaluated with μ Fourier transform infrared spectroscopy, Raman spectroscopy, and energy dispersive radiographs. RESULTS Thirty-six patients (median [range] age, 64 [33-89] years; 26 [72%] female) were included, and 29 cutaneous biopsies were analyzed. Calcific uremic arteriolopathy and arteriolosclerosis skin calcifications were composed of pure calcium-phosphate apatite. Calcific uremic arteriolopathy vascular calcifications were always circumferential, found in small to medium-sized vessels, with interstitial deposits in 22 (76%) of the samples. A thrombosis, most often in noncalcified capillary lumens in the superficial dermis, was seen in 5 samples from patients with CUA. Except for calcium deposits, the vessel structure of patients with CUA appeared normal, unlike thickened arteriolosclerotic vessel walls. Twelve (33%) patients died of CUA. CONCLUSIONS AND RELEVANCE Calcific uremic arteriolopathy-related skin calcifications were exclusively composed of pure calcium-phosphate apatite, localized circumferentially in small to medium-sized vessels and often associated with interstitial deposits, suggesting its pathogenesis differs from that of arteriolosclerosis. Although the chemical compositions of CUA and arteriolosclerosis calcifications were similar, the vessels' appearances and deposit localizations differed, suggesting different pathogenetic mechanisms.

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Untitled

Cited by 18 publications

References 0 publications

<p>Could Inflammaging and Its Sequelae Be Prevented or Mitigated?</p>

<p>Could Inflammaging and Its Sequelae Be Prevented or Mitigated?</p>

Influence of “Not Relevant” Responses on the Dermatology Life Quality Index (DLQI) for Patients With Psoriasis in the United States

Localization, Morphologic Features, and Chemical Composition of Calciphylaxis-Related Skin Deposits in Patients With Calcific Uremic Arteriolopathy

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