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OCHIAI-OHIRA, Tomomi; KURASHIMA, Osamu; Akami, Rie; Hasegawa, Toshikazu; HIRAI, Momoki; MATSUZAWA, Teturo; Yoshikawa, Yasuhiro

doi:10.2354/psj.22.123

Cited by 9 publications

References 18 publications

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The first chimpanzee sanctuary in Japan: an attempt to care for the “surplus” of biomedical research

Morimura

Idani

Matsuzawa

2010

American J Primatol

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This article specifically examines several aspects of the human-captive chimpanzee bond and the effort to create the first chimpanzee sanctuary in Japan. We discuss our ethical responsibility for captive chimpanzees that have been used in biomedical research. On April 1, 2007, the Chimpanzee Sanctuary Uto (CSU) was established as the first sanctuary for retired laboratory chimpanzees in Japan. This initiative was the result of the continuous efforts by members of Support for African/Asian Great Apes (SAGA), and the Great Ape Information Network to provide a solution to the large chimpanzee colony held in biomedical facilities. However, the cessation of invasive biomedical studies using chimpanzees has created a new set of challenges because Japan lacks registration and laws banning invasive ape experiments and lacks a national policy for the life-long care of retired laboratory chimpanzees. Therefore, CSU has initiated a relocation program in which 79 retired laboratory chimpanzees will be sent to domestic zoos and receive life-long care. By the end of 2009, the number of chimpanzees living at CSU had decreased from 79 to 59 individuals. A nationwide network of care facilities and CSU to provide life-long care of retired laboratory chimpanzees is growing across Japan. This will result in humane treatment of these research animals.

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The first chimpanzee sanctuary in Japan: an attempt to care for the “surplus” of biomedical research

Morimura

Idani

Matsuzawa

2010

American J Primatol

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Molecular Behavioral Research in Great Apes

Inoue‐Murayama

Weiss

Morimura

et al. 2011

From Genes to Animal Behavior

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Unpredictable Chronic Stress-Induced Reproductive Suppression Associated with the Decrease of Kisspeptin Immunoreactivity in Male Mice

et al. 2014

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Environmental stress affects various parts of mammals typically through the circulation of stress hormones. It has been identified as one of the possible reasons for male reproductive difficulties, but the complex mechanisms responsible for stress-induced reproductive suppression are poorly understood. Here, we examined the relationship between chronic environmental stress and hypothalamic kisspeptin, a recently discovered upstream regulator of the reproductive endocrine feedback system. We studied male mice under an unpredictable chronic stress procedure to replicate the situation of animals under chronic stress. Histological and immunohistochemical analyses were performed focusing on kisspeptin neurons in the arcuate hypothalamic nucleus (ARC) and DNA fragmented cells in seminiferous tubules. Although the ARC was not morphologically altered in either the stressed or non-stressed group, granular kisspeptin immunoreactivities decreased slightly in the stress group. In the testes of the stress group, several signs of testicular degeneration were observed, including increased numbers of ssDNA-positive cells per seminiferous tubule, thinning, vacuoled seminiferous epithelia and multinucleated giant cells. The decreases in kisspeptin in the stress group might be due to other hypothalamic peptides, such as corticotropin-releasing hormone and leptin, whose receptors are known to coexpress in the ARC. In addition, environmental stress directly and indirectly affects testicular function through stress hormones and gonadotropins. In summary, our findings enhance the understanding of stress-induced reproductive suppression possibly mediated by kisspeptin in the ARC.

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Abstract: 落合-大平知美１) ・倉島治２) ・赤見理恵３) ・長谷川寿一４) ・平井百樹５) ・松沢哲郎１) ・吉川泰弘２)

Cited by 9 publications

References 18 publications

The first chimpanzee sanctuary in Japan: an attempt to care for the “surplus” of biomedical research

The first chimpanzee sanctuary in Japan: an attempt to care for the “surplus” of biomedical research

Molecular Behavioral Research in Great Apes

Unpredictable Chronic Stress-Induced Reproductive Suppression Associated with the Decrease of Kisspeptin Immunoreactivity in Male Mice

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Abstract: 落合-大平知美 １) ・倉島治 ２) ・赤見理恵 ３) ・長谷川寿一 ４) ・ 平井百樹 ５) ・松沢哲郎 １) ・吉川泰弘 ２)

Cited by 9 publications

References 18 publications

The first chimpanzee sanctuary in Japan: an attempt to care for the “surplus” of biomedical research

The first chimpanzee sanctuary in Japan: an attempt to care for the “surplus” of biomedical research

Molecular Behavioral Research in Great Apes

Unpredictable Chronic Stress-Induced Reproductive Suppression Associated with the Decrease of Kisspeptin Immunoreactivity in Male Mice

Contact Info

Product

Resources

About

Abstract: 落合-大平知美１) ・倉島治２) ・赤見理恵３) ・長谷川寿一４) ・平井百樹５) ・松沢哲郎１) ・吉川泰弘２)