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Masuda, Akinori; Munemoto, Takao; Yamanaka, Takao; Takei, Michiko; Tei, Chuwa

doi:10.1023/a:1020423124675

Cited by 17 publications

(6 citation statements)

References 17 publications

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“…Clinically, psychiatric disorders are common among patients with chronic fatigue or chronic fatigue syndrome [3]. Research has demonstrated that both the occurrence of recent stressful life events and chronic stress levels appear to be increased in patients with chronic fatigue or chronic fatigue syndrome [17–20]. …”

Section: Introductionmentioning

confidence: 99%

A Randomized Controlled Trial of Qigong Exercise on Fatigue Symptoms, Functioning, and Telomerase Activity in Persons with Chronic Fatigue or Chronic Fatigue Syndrome

Chan

Wang

et al. 2012

ann. behav. med.

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BackgroundChronic fatigue is common in the general population. Complementary therapies are often used by patients with chronic fatigue or chronic fatigue syndrome to manage their symptoms.PurposeThis study aimed to assess the effect of a 4-month qigong intervention program among patients with chronic fatigue or chronic fatigue syndrome.MethodsSixty-four participants were randomly assigned to either an intervention group or a wait list control group. Outcome measures included fatigue symptoms, physical functioning, mental functioning, and telomerase activity.ResultsFatigue symptoms and mental functioning were significantly improved in the qigong group compared to controls. Telomerase activity increased in the qigong group from 0.102 to 0.178 arbitrary units (p < 0.05). The change was statistically significant when compared to the control group (p < 0.05).ConclusionQigong exercise may be used as an alternative and complementary therapy or rehabilitative program for chronic fatigue and chronic fatigue syndrome.

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Section: Introductionmentioning

confidence: 99%

A Randomized Controlled Trial of Qigong Exercise on Fatigue Symptoms, Functioning, and Telomerase Activity in Persons with Chronic Fatigue or Chronic Fatigue Syndrome

Chan

Wang

et al. 2012

ann. behav. med.

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“…High emotional instability has been associated with CFS in a variety of studies (15-21). Of particular importance for the present study, in a large population-based, longitudinal, co-twin control analysis, Kato and colleagues (22) found that emotional instability, assessed 25 years earlier, predicted chronic impairing fatigue and CFS-like illness through non-causal shared genetic mechanisms common to both emotional instability and fatiguing illness.…”

Section: Introductionmentioning

confidence: 99%

“…Several studies have noted low extraversion in patients with CFS (16) and fibromyalgia (20, 27), but these findings have not been consistent (28). In addition, Masuda and colleagues found higher levels of extraversion in post-infectious but not non-infectious CFS patients (21). The longitudinal co-twin control study described above found no association between extraversion at baseline and chronic fatigue 25 years later, after adjusting for emotional instability (22).…”

Section: Introductionmentioning

confidence: 99%

Chronic Fatigue and Personality: A Twin Study of Causal Pathways and Shared Liabilities

et al. 2013

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Background The etiology of chronic fatigue syndrome (CFS) remains unknown. Personality traits influence well-being and may play a role in CFS and unexplained chronic fatigue. Purpose To examine the association of emotional instability and extraversion with chronic fatigue and CFS in a genetically informative sample. Methods We evaluated 245 twin pairs for two definitions of chronic fatigue. They completed the Neuroticism and Extraversion subscales of the NEO-FFI. Using a co-twin control design, we examined the association between personality and chronic fatigue. Results Higher emotional instability was associated with both definitions of chronic fatigue and was confounded by shared genetics. Lower extraversion was also associated with both definitions of fatigue, but was not confounded by familial factors. Conclusions Both emotional instability and extraversion are related to chronic fatigue and CFS. Whereas emotional instability and chronic fatigue are linked by shared genetic mechanisms, the relationship with extraversion may be causal and bi-directional.

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“…When the onset of FGID or CFS is associated with an acute infection, it is often termed post-infectious CFS (PI-CFS) [18,19] or FGID (PI-FGID) [20] or in the case of IBS, post-infectious IBS (PI-IBS) [9]. A meta-analysis of PI-IBS estimates that the risk of having IBS one year after an acute gastroenteritis is approximately sixfold [21].…”

Section: Introductionmentioning

confidence: 99%

Immunophenotyping in post-giardiasis functional gastrointestinal disease and chronic fatigue syndrome

et al. 2012

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BackgroundA Giardia outbreak was associated with development of post-infectious functional gastrointestinal disorders (PI-FGID) and chronic fatigue syndrome (PI-CFS). Markers of immune dysfunction have given conflicting results in CFS and FGID patient populations. The aim of this study was to evaluate a wide selection of markers of immune dysfunction in these two co-occurring post-infectious syndromes.Methods48 patients, reporting chronic fatigue in a questionnaire study, were clinically evaluated five years after the outbreak and grouped according to Fukuda criteria for CFS (n=19) and idiopathic chronic fatigue (n=5) and Rome II criteria for FGIDs (n=54). 22 Giardia exposed non-fatigued individuals and 10 healthy unexposed individuals were recruited as controls. Peripheral blood lymphocyte subsets were analyzed by flow cytometry.ResultsIn peripheral blood we found significantly higher CD8 T-cell levels in PI-FGID, and significantly lower NK-cell levels in PI-CFS patients. Severity of abdominal and fatigue symptoms correlated negatively with NK-cell levels. A tendency towards lower T-cell CD26 expression in FGID was seen.ConclusionPatients with PI-CFS and/or PI-FGID 5 years after Giardia lamblia infection showed alterations in NK-cell and CD8-cell populations suggesting a possible immunological abnormality in these conditions. We found no significant changes in other markers examined in this well-defined group of PI-CFS and PI-FGID elicited by a gastrointestinal infection. Controlling for co-morbid conditions is important in evaluation of CFS-biomarkers.

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Cited by 17 publications

References 17 publications

A Randomized Controlled Trial of Qigong Exercise on Fatigue Symptoms, Functioning, and Telomerase Activity in Persons with Chronic Fatigue or Chronic Fatigue Syndrome

A Randomized Controlled Trial of Qigong Exercise on Fatigue Symptoms, Functioning, and Telomerase Activity in Persons with Chronic Fatigue or Chronic Fatigue Syndrome

Chronic Fatigue and Personality: A Twin Study of Causal Pathways and Shared Liabilities

Immunophenotyping in post-giardiasis functional gastrointestinal disease and chronic fatigue syndrome

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