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Charbon, V; Latour, Isabelle; Lambert, Didier M.; Buc-Calderon, Pedro; Neuvens, L; Keyser, J.-L. De; Gallez, Bernard

doi:10.1023/a:1016012913664

Cited by 12 publications

(2 citation statements)

References 13 publications

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“…Fatty acids, such as oleic acid, possess a high affinity for hepatocytes. Their efficient cellular uptake is the result of a specific interaction with the Fatty Acid Binding Protein (h-FABP) present at the sinusoidal pole of the hepatocyte [93].…”

Section: Mechanism Of Sg-ligands For Liver-targeting Of Hepg2 Cellsmentioning

confidence: 99%

Application of Sterylglucoside-Containing Particles for Drug Delivery

Maitani¹,

Nakamura²,

Kawano

2005

CPB

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Recent advances in biotechnology have promoted biomolecular targeting of drugs, peptides and genes in the treatment and management of major diseases and infections. Therapeutic development of drugs and delivery systems may have various objectives: Systemic drugs require optimal delivery and uptake at target sites; peptide drugs require alternative routes of administration, such as nasal or intestinal absorption; gene medicines need to be delivered efficiently, safely and selectively to diseased areas. The propensity of ligand-modified liposomes to carry drugs and genes to desirable sites has been extensively examined and current reports show considerable progress in this field. Sterylglucoside (SG) is a novel absorption-enhancer of peptide drugs across nasal and intestinal mucosae. Physico-chemical properties and biodistribution of liposomes incorporating SG were studied and compared against the profiles of aglycon and sitosterol derivatives of SG. It was shown that SG particles aided colon drug delivery and increased bioavailability of peptide drugs after nasal and intestinal administration. In addition, they were able to enhance anticancer effects in liver cancer chemotherapy. Biological fate and interaction of SG with hepatocytes support the novel proposition of liver-targeting SG-liposomes.

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Section: Mechanism Of Sg-ligands For Liver-targeting Of Hepg2 Cellsmentioning

confidence: 99%

Application of Sterylglucoside-Containing Particles for Drug Delivery

Maitani¹,

Nakamura²,

Kawano

2005

CPB

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“…This half-life converts albumin into an attractive carrier to enhance and improve the pharmacokinetic properties of cancer agents [ 30 – 35 ]. In addition to being the most important transporter of fatty acids and drugs, this protein also acts as a catalyst in the hydrolysis of esters and hopes and phosphates [ 36 , 37 ]. In addition, albumin itself has a therapeutic role and is used in various formulations to carry pharmacological and diagnostic agents [ 38 ].…”

Section: Introductionmentioning

confidence: 99%

Theoretical aspects of interaction of the anticancer drug cytarabine with human serum albumin

Amirinasab

Dehestani

2023

Struct Chem

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Despite diagnostic and therapeutic methods, cancer is a major cause of death worldwide. Since anticancer drugs affect both normal and cancer cells, targeted drug delivery systems can play a key role in reducing the destructive effects of anticancer drugs on normal cells. In this regard, the use of stimulus-sensitive polymers has increased in recent years. This study has attempted to investigate interaction of the anticancer drug cytarabine with a stimuli-sensitive polymer, human serum albumin (HSA), one of the most abundant protein in blood plasma, via computational methods at both body temperature and tumor temperature. For this purpose, molecular docking was performed using Molegro virtual Docker software to select the best ligand in terms of binding energy to simulate molecular dynamics. Then, molecular dynamics simulation was performed on human serum albumin with code (1Ao6) and cytarabine with code (AR3), using Gromacs software and the results were presented in the graphs. The simulations were performed at 310 K (normal cell temperature) and 313 K (cancer cell temperature) in 100 ns. Results showed drug release occurred at a temperature of 313 K. These findings demonstrated the sensitivity of human serum albumin to temperature.

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Lipidic prodrug approach for improved oral drug delivery and therapy

Marković

Ben‐Shabat

Keinan

et al. 2018

Medicinal Research Reviews

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In the past, a prodrug design was used as a last option to improve bioavailability through controlling transport, distribution, metabolism, or other mechanisms. Prodrugs are currently used even in early stages of drug development, and a significant percentage of all drugs in the market are prodrugs. The focus of this article is lipidic prodrugs, a strategy whereby a lipid carrier is covalently bound to the drug moiety. The increased lipophilicity of the lipid-drug conjugate can improve the pharmacokinetic profile and provide meaningful advantages: increased absorption across biological barriers, prolonged circulation half-life, selective distribution profile (eg brain penetration), reduced hepatic first-pass metabolism, and overall enhanced bioavailability of the parent drug. Moreover, lipidic prodrugs may join the endogenous lipid trafficking pathways, thereby facilitate drug targeting, either by selective absorption pathway (eg lymphatic transport) or drug release at specific target site(s).The different lipid-drug conjugates (triglyceride-, fatty acids, phospholipid-, and steroid-based prodrugs), the physiological barriers that challenge the absorption of these conjugates, followed by their current utilization and potential clinical benefits are described and analyzed, and future opportunities this approach could provide are discussed.Altogether, lipidic prodrugs represent an exciting approach for improving different aspects of oral drug delivery/therapy and may provide solutions for various unmet needs; the use of this strategy is expected to grow.

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Abstract: This study showed the convenience in using fatty acids as drug carriers possessing tropism for the hepatocytes.

Cited by 12 publications

References 13 publications

Application of Sterylglucoside-Containing Particles for Drug Delivery

Application of Sterylglucoside-Containing Particles for Drug Delivery

Theoretical aspects of interaction of the anticancer drug cytarabine with human serum albumin

Lipidic prodrug approach for improved oral drug delivery and therapy

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