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Brusentsov, N. A.; Baiburtskii, F. S.; Tarasov, V. V.; Komissarova, L. Kh.; Filippov, Victor I.

doi:10.1023/a:1019888706350

Cited by 8 publications

(5 citation statements)

References 33 publications

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“…Such oligonucleotide-functionalised magnetic nanoparticles can be taken up intracellularely by endocytosis [308]. Nanoparticles may be applied in tumour diagnosis and therapy [309]. The nanoparticles have several advantages such as high drug encapsulation, efficient drug protection against chemical or enzymatic degradation, unique ability to create a controlled release of drugs, cell internalisation and the ability to reverse the multidrug resistance of tumour cells [310].…”

Section: Cmd As Coating Materialsmentioning

confidence: 99%

Functional Polymers Based on Dextran

Heinze

Liebert

Heublein

et al.

Advances in Polymer Science

248

198

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Dextran, comprising a family of neutral polysaccharides consisting of an α-(1→6) linked d-glucose main chain with varying proportions of linkages and branches, depending on the bacteria used, is an interesting starting material for chemical modification reactions for the design of new functional polymers with promising properties. The review summarises recent results on structure characterisation of dextran including some comments on biosynthesis of this important class of biopolymers. Applications of dextran are discussed as well. Chemical modification reactions of dextran are increasingly studied for the structure and hence property design. The review highlights recent progress in esterification of dextran, both inorganic and organic polysaccharide esters, etherification reactions towards ionic and non-ionic ethers, and the huge variety of different conversions mainly developed for the binding of drugs. It summarises recent developments in the application of dextran derivatives with a focus on the chemical structures behind these materials such as prodrugs, bioactivity of inorganic dextran esters, heparin sulfate mimics, hydrogels, nanoparticles and self assembly structures for surface modification. Keywords Functionalised dextran • Structural analysis • Prodrugs • Nanostructures • Bioactivity Abbreviations AFM Atomic force microscopy AGU Anhydroglucose units AT Antithrombin AZT Azidothymidine BSH Na 2 B 12 H 11 SH BSA Bovine serum albumin CAC Critical association concentration CDI N,N -Carbonyldiimidazole CMC Critical micelle concentration CMD Carboxymethyl dextran CMDB Carboxymethyl dextran benzylamide CMDBSSu Carboxymethyl dextran benzylamidesulfonate sulfate CMDBSu Carboxymethyl dextran benzylamide sulfate CMDEE Carboxymethyl dextran ethyl ester CMDSu Carboxymethyl dextran sulfate COSY Two-dimensional correlated spectroscopy CsA Cyclosporin A 2D Two-dimensional Dach-Pt cis-Dihydroxo(cyclohexane-trans-l-1,2-diamine)platinum II DCC N,N -Dicyclohexylcarbodiimide T. Heinze et al.

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Section: Cmd As Coating Materialsmentioning

confidence: 99%

Functional Polymers Based on Dextran

Heinze

Liebert

Heublein

et al.

Advances in Polymer Science

248

198

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“…So-called “smart gels” are able to swell or shrink up to 1000 times in response to small changes in temperature, pH, electric fields or solvent and ionic composition [27]. Due to the hysteresis loss from the magnetic particles, the temperature of the system increases and it crosses the lower critical solution temperature (LCST), thermo-responsive gels undergo large contraction and may deliver drug molecules entrapped in their networks in a controlled manner [26,28] (Figure 1).…”

Section: Introductionmentioning

confidence: 99%

Magnetic Gel Composites for Hyperthermia Cancer Therapy

Häring

Schiller

Mayr

et al. 2015

Gels

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Hyperthermia therapy is a medical treatment based on the exposition of body tissue to slightly higher temperatures than physiological (i.e., between 41 and 46 °C) to damage and kill cancer cells or to make them more susceptible to the effects of radiation and anti-cancer drugs. Among several methods suitable for heating tumor areas, magnetic hyperthermia involves the introduction of magnetic micro/nanoparticles into the tumor tissue, followed by the application of an external magnetic field at fixed frequency and amplitude. A very interesting approach for magnetic hyperthermia is the use of biocompatible thermo-responsive magnetic gels made by the incorporation of the magnetic particles into cross-linked polymer gels. Mainly because of the hysteresis loss from the magnetic particles subjected to a magnetic field, the temperature of the system goes up and, once the temperature crosses the lower critical solution temperature, thermo-responsive gels undergo large volume changes and may deliver anti-cancer drug molecules that have been previously entrapped in their networks. This tutorial review describes the main properties and formulations of magnetic gel composites conceived for magnetic hyperthermia therapy.

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“…This problem has been considered in a number of works (see reviews [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15]) devoted mainly to bio detection/biosensitivity [1][2][3] (plasmon resonant properties of gold and silver nanoparticles are used in this field [16,17]) and cancer treatment. In the latter case, gold [4][5][6][7] and silver [8] NPs, as well as magnetic particles [9,[18][19][20], are mainly used as carriers of drugs [4, 5, 9-11, 14, 18-20] and intensifiers of physiotherapeutic treatment methods-radiation, photodynamic, and photothermal therapy [3,6,7,12,[21][22][23].…”

Section: Introductionmentioning

confidence: 99%

Heterocoagulation of polysaccharide-coated platinum nanoparticles with ovarian-cancer cells

et al. 2014

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Platinum nanoparticles coated with adsorption layers of polysaccharides of Chlorella vulgaris (Pt PS ) have been synthesized and their heterocoagulation with human ovarian cancer cells of the A2780 line has been studied. It has been shown that the characteristic time of the aggregation of the cells with Pt PS nano particles is 20-25 min, which corresponds to fast barrierless coagulation. The cytotoxic effect of Pt PS nano particles reaches saturation and more than 50% of the cells die within this time period. Cytomorphological investigations have shown that A2780 cells with doubled resistance to an antitumoral antibiotic, doxorubicin, are more sensitive to the toxic action of Pt PS nanoparticles than nonresistant cells are. An electrokinetic con trol test has been proposed for cancer cell resistance based on the measurement of variations in the ζ poten tial of nanoparticles due to adsorption of water soluble metabolites of the cells on a particle surface.

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Untitled

Cited by 8 publications

References 33 publications

Functional Polymers Based on Dextran

Functional Polymers Based on Dextran

Magnetic Gel Composites for Hyperthermia Cancer Therapy

Heterocoagulation of polysaccharide-coated platinum nanoparticles with ovarian-cancer cells

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