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Reedy, Dennis W; Loo, Alice; Levine, Robert A.

doi:10.1023/a:1018888021118

Cited by 67 publications

(7 citation statements)

References 10 publications

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“…(1998), this test cannot predict significant cirrhosis in patients with chronic hepatitis C [30]. We also observed slightly low Hb levels in HCV patients irrespective of genotype.…”

Section: Discussionmentioning

confidence: 73%

Association of laboratory parameters with viral factors in patients with hepatitis C

Ijaz

Ahmad

Javed

et al. 2011

Virol J

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Background and AimsHCV infection may lead to hepatic fibrosis. In this study, we tried to determine whether there is any correlation of HCV genotypes and viral load to the clinical parameters such as ALT, AST, ALP, bilirubin, Hb level, patient's age and gender; and then correlated this association with disease progression in liver biopsy samples.MethodsIn cross-sectional and observational study, 6048 serum HCV RNA positive patients were chosen. The study consists of 53 months from March 2006 to September 2010. Patients were divided into three cohorts to validate our data. Statistical analysis and correlation of lab parameters with viral factors was determined by using SPSS version 16.ResultsThe most prevalent genotype was 3 (70.9%) followed by 1 (13.3%) and 4 (7.4%), collectively. During Univariate analysis, in all cohorts; serum bilirubin, ALP, ALT and AAR showed significant correlation with genotypes, however multivariate analysis showed that all genotypes except 4a have no association with host biochemical markers. Disease progression was also independent of all genotypes. Serum ALP, ALT, bilirubin and viremea levels were significantly elevated in patients with genotype 4a. Viral load showed negative association with serum bilirubin (r = -0.112, P = 0.000) and ALP levels (r = -0.098, P = 0.000). We observed positive correlation of ALP and bilirubin levels, while negative associations of viral load with HCV liver disease progression.ConclusionDisease progression seems independent of the genotypes. Relationship between ALP and bilirubin with viral load may be an attractive marker to guess disease progression in patients with hepatitis C.

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“…(1998), this test cannot predict significant cirrhosis in patients with chronic hepatitis C [30]. We also observed slightly low Hb levels in HCV patients irrespective of genotype.…”

Section: Discussionmentioning

confidence: 73%

Association of laboratory parameters with viral factors in patients with hepatitis C

Ijaz

Ahmad

Javed

et al. 2011

Virol J

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“…Serum aspartate aminotransferases (AST) levels are even more important predictors of histological activity than ALT,37,38 and the ratio of AST/ALT > 1 (AAR) has been proposed as a test of cirrhosis 39,40. However, the diagnostic accuracy of this ratio is highly variable among different studies 41–43…”

Section: Hepatic Fibrogenesis and Its Molecular Serum Markersmentioning

confidence: 99%

Molecular Serum Markers of Liver Fibrosis

et al. 2012

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Fibrosis is a hallmark histologic event of chronic liver diseases and is characterized by the excessive accumulation and reorganization of the extracellular matrix (ECM). The gold standard for assessment of fibrosis is liver biopsy. As this procedure has various limitations, including risk of patient injury and sampling error, a non-invasive serum marker for liver fibrosis is desirable. The increasing understanding of the pathogenesis of hepatic fibrosis has suggested several markers which could be useful indicators of hepatic fibrogenesis and fibrosis. These markers include serum markers of liver function, ECM synthesis, fibrolytic processes, ECM degradation and fibrogenesis related cytokines. Recently, neo-epitopes, which are post-translational modifications of proteins, have been successfully used in bone and cartilage diseases which are characterized by extensive ECM remodeling. Increasing numbers of studies are being undertaken to identify neo-epitopes generated during liver fibrosis, and which ultimately might be useful for diagnosing and monitoring fibrogenesis. To date, the metalloproteinases generated fragment of collagen I, III, IV and VI have been proven to be elevated in two rat models of fibrosis. This review summarizes the recent efforts that have been made to identify potentially reliable non-invasive serum markers. We used the recently proposed BIPED (Burden of disease, Investigative, Prognostic, Efficacy and Diagnostic) system to characterize potential serum markers and neo-epitope markers that have been identified to date.

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“…However, not all studies are in agreement and the prognostic information of an increased AAR seems to be similar to that provided by other established prognostic scores in cirrhotic patients. [ 14–16 ] In a sample of patients with non-alcoholic steatohepatitis, an AAR of ≥1 strongly suggested the presence of cirrhosis [17] . Recently, an increased AAR was also found to be independently associated with the risk of developing cardiovascular (CV) diseases, especially in men [18] …”

Section: Introductionmentioning

confidence: 99%

The aspartate aminotransferase-to-alanine aminotransferase ratio predicts all-cause and cardiovascular mortality in patients with type 2 diabetes

Zoppini

Cacciatori²,

Negri³

et al. 2016

Medicine

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An increased aspartate aminotransferase-to-alanine aminotransferase ratio (AAR) has been widely used as a marker of advanced hepatic fibrosis. Increased AAR was also shown to be significantly associated with the risk of developing cardiovascular (CV) disease. The aim of this study was to assess the relationship between the AAR and mortality risk in a well-characterized cohort of patients with type 2 diabetes.A cohort of 2529 type 2 diabetic outpatients was followed-up for 6 years to collect cause-specific mortality. Cox regression analyses were modeled to estimate the independent association between AAR and the risk of all-cause and CV mortality.Over the 6-year follow-up period, 12.1% of patients died, 47.5% of whom from CV causes. An increased AAR, but not its individual components, was significantly associated with an increased risk of all-cause (adjusted-hazard risk 1.83, confidence interval [CI] 95% 1.14–2.93, P = 0.012) and CV (adjusted-hazard risk 2.60, CI 95% 1.38–4.90, P < 0.003) mortality after adjustment for multiple clinical risk factors and potential confounding variables.The AAR was independently associated with an increased risk of both all-cause and CV mortality in patients with type 2 diabetes. These findings suggest that an increased AAR may reflect more systemic derangements that are not simply limited to liver damage. Further studies are needed to elucidate the pathophysiological implications of an increased AAR.

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Untitled

Cited by 67 publications

References 10 publications

Association of laboratory parameters with viral factors in patients with hepatitis C

Association of laboratory parameters with viral factors in patients with hepatitis C

Molecular Serum Markers of Liver Fibrosis

The aspartate aminotransferase-to-alanine aminotransferase ratio predicts all-cause and cardiovascular mortality in patients with type 2 diabetes

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