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Rastogi, Suneel; Zakrzewski, Marek; Suryanarayanan, Raj

doi:10.1023/a:1020386321876

Cited by 13 publications

(2 citation statements)

References 12 publications

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“…Variable-temperature X-ray powder diffraction (VTXRPD) analysis has been used to characterize complex pharmaceutical solid-state reactions including crystal transformations [12,13]. This technique is a powerful tool that is used to probe such reactions since it permits simultaneous quantification of multiple solid phases [14,15]. XRPD was also used to determine the effect of heat generated during compression on the transformation of Form C. The results of this study are important since currently there are no official methods to characterize the crystal forms of mebendazole.…”

Section: Introductionmentioning

confidence: 99%

Variable-temperature X-ray powder diffraction analysis of the crystal transformation of the pharmaceutically preferred polymorph C of mebendazole

Villiers

Terblanche

Liebenberg

et al. 2005

Journal of Pharmaceutical and Biomedical Analysis

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Section: Introductionmentioning

confidence: 99%

Variable-temperature X-ray powder diffraction analysis of the crystal transformation of the pharmaceutically preferred polymorph C of mebendazole

Villiers

Terblanche

Liebenberg

et al. 2005

Journal of Pharmaceutical and Biomedical Analysis

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“…These kind of nanocomposites find wide application in bioavailability enhancement of poorly watersoluble drugs. 8 Owing to their complex microstructure, the nanocomposites were investigated by coupling differential scanning calorimetry (DSC) and temperature resolved XRD, which was already successfully applied to track phase transitions of drugs, 45,46 and implemented for quantitative analysis of drug/polymer composites. 47 The coherent domain size of the nanocrystals was independently evaluated by XRD profile analysis and from melting point depression data.…”

Section: Introductionmentioning

confidence: 99%

Melting of Nanostructured Drugs Embedded into a Polymeric Matrix

et al. 2004

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The melting behavior of nanostructured organic materials (drugs) embedded into a cross-linked polymeric matrix was studied for the first time. The complex microstructure of these nanocomposites, yielded by the polymer matrix in which molecular clusters and nanocrystals of drug plus a cospiquous fraction of water are confined, demanded synergic application of thermal analysis and temperature resolved X-ray diffraction. A relevant depression of the melting point of the embedded drug with respect to the bulk drug was experimentally demonstrated. The coherent domain size of the embedded drug nanocrystals was independently evaluated by thermal and diffraction data and results were in agreement. This indicates that the adopted thermodynamic melting model, based on Laplace and Gibbs−Duhem equations and developed for simpler systems, can be successfully assessed for describing drug/polymer nanocomposites, and, potentially, other classes of organic nanocomposites.

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