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Sills, E. Scott; Goldschlag, Dan; Dp, Levy; Ok, Davis; Rosenwaks, Zev

doi:10.1023/a:1020588902509

Cited by 12 publications

(1 citation statement)

References 13 publications

(8 reference statements)

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“…In PGD, a blastomere from a four-to eight-cell embryo is biopsied and subjected to DNA analysis either by fluorescent in-situ hybridization (FISH) for chromosome labeling, or by fluorochrome PCR based assay for specific gene identification. This does not negatively affect the viability of the embryo, which will be transferred if it has the desired sex [10]. In all cases, patients must be carefully counseled prior to this procedure since it is associated with a higher than anticipated failure rate related to lack of desired embryos for transfer.…”

Section: Sex Selection For Etmentioning

confidence: 99%

Effect of injecting slowly motile sperms in intracytoplasmic sperm injection cases with sex selection: a randomized controlled trial

Elsharkawy,

Hussein Khalil,

Elgazayerli

2024

Ital J Gynaecol Obstet

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Objective. To compare injecting slowly motile sperms versus rapidly motile ones in PGD cases requesting sex selection for family balance. Materials and Methods.A prospective, randomized controlled clinical trial was done from January 2020 to July 2022. 132 patients seeking ICSI for sex selection in Engab private infertility center, Alexandria, Egypt, were included. Spermatozoa with slowly progressive motility were selected and used for ICSI (group A=94), and spermatozoa with rapidly progressive motility were selected and used for ICSI (group B=38). Day 3 after fertilization, pre-implantation genetic diagnosis (PGD) regarding the gender of the resulted embryos were performed, recorded and compared. Results.As regards the number of resulted embryos, there was no statistical significant difference between both groups (mean ± SD = 5.26 ± 2.17 for group A, 6.16 ± 2.76 for group B, P= 0.052). The percentage of male embryos to the total embryos was calculated and compared, but there were no statistical differences between groups (% mean ± SD = 36.29 ± 20.82 for group A, 33.99 ± 15.30 for group B, P = 0.442). On the other hand, there was a statistically significant difference when female embryo percentages were compared between groups, in favor of group B (% mean ± SD = 22.78 ± 22.73 for group A, 30.25 ± 20.45, P= 0.031). Conclusions.Using slowly motile sperms in ICSI cases requiring sex selection, yielded more male embryos, but did not reach statistically significance. On the contrary, using rapidly motile sperms yielded more female embryos and achieved a statistical significant difference.

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Section: Sex Selection For Etmentioning

confidence: 99%

Effect of injecting slowly motile sperms in intracytoplasmic sperm injection cases with sex selection: a randomized controlled trial

Elsharkawy,

Hussein Khalil,

Elgazayerli

2024

Ital J Gynaecol Obstet

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Issues and concerns of couples presenting for preimplantation genetic diagnosis (PGD)

et al. 2002

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All groups found PGD to be a highly acceptable treatment. They expressed little concern about its extension to testing non-disease states such as sex and they were strongly in favour of a shared decision-making model in which couples have considerable autonomy over decisions about the embryo(s) to transfer. Differences between the groups included issues surrounding the transfer of embryos, restrictions to PGD and the destruction of embryos.

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Personal desires of patients and social obligations of geneticists: applying preimplantation genetic diagnosis for non‐medical sex selection

Pennings¹

2002

Prenatal Diagnosis

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The arguments against the use of preimplantation genetic diagnosis (PGD) for non-medical sex selection are analysed. It is concluded that the distinction between medical and non-medical reasons is difficult to maintain, that the disproportionality of means and end is not a decisive counterargument and that the fear of damage to the reputation of PGD does not justify the refusal of controversial applications. Moreover, since non-medical sex selection does not belong to basic health care, it should not be equally accessible to all. The position defended in this article is founded on two basic principles: (1). medical reasons have priority on non-medical reasons, and (2). personal reasons do not qualify for public funding. In order to respect both principles, it is proposed that restrictions should be installed to control the number of requests for social sexing and that a tax should be imposed on these elective services. The tax should compensate the society for the investment it made in the training and education of the physician.

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Untitled

Cited by 12 publications

References 13 publications

Effect of injecting slowly motile sperms in intracytoplasmic sperm injection cases with sex selection: a randomized controlled trial

Effect of injecting slowly motile sperms in intracytoplasmic sperm injection cases with sex selection: a randomized controlled trial

Issues and concerns of couples presenting for preimplantation genetic diagnosis (PGD)

Personal desires of patients and social obligations of geneticists: applying preimplantation genetic diagnosis for non‐medical sex selection

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