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Petty, Frederick; Jordan, Scott W.; Kramer, Gerald L.; Zukas, Paul K.; Wu, Jianhua

doi:10.1023/a:1027309117349

Cited by 25 publications

(2 citation statements)

References 11 publications

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“…While daily restraint stress for 6 consecutive days results in a habituation of the extracellular dopamine response in the NAc across time, when restraint is again repeated after 72 h, the extracellular dopamine phasic response in the NAc is equivalent to the response on the first day (Imperato et al 1992; Imperato et al 1993). Repeated footshock stress (Young 2004) and intermittent social defeat stress (Holly et al 2015), on the other hand, do not show such habituation in the phasic extracellular NAc dopamine response, while a sensitized response is observed after the much milder stresses of repeated tail pinch (Naef et al 2013) or forced swim (Jordan et al 1994; Petty et al 1997). …”

Section: Introductionmentioning

confidence: 99%

Ventral tegmental area dopamine revisited: effects of acute and repeated stress

2015

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Aversive events rapidly and potently excite certain dopamine neurons in the ventral tegmental area (VTA), promoting phasic increases in the medial prefrontal cortex and nucleus accumbens. This is in apparent contradiction to a wealth of literature demonstrating that most VTA dopamine neurons are strongly activated by reward and reward-predictive cues while inhibited by aversive stimuli. How can these divergent processes both be mediated by VTA dopamine neurons? The answer may lie within the functional and anatomical heterogeneity of the VTA. We focus on VTA heterogeneity in anatomy, neurochemistry, electrophysiology, and afferent/efferent connectivity. Second, recent evidence for a critical role of VTA dopamine neurons in response to both acute and repeated stress will be discussed. Understanding which dopamine neurons are activated by stress, the neural mechanisms driving the activation, and where these neurons project will provide valuable insight into how stress can promote psychiatric disorders associated with the dopamine system, such as addiction and depression.

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Section: Introductionmentioning

confidence: 99%

Ventral tegmental area dopamine revisited: effects of acute and repeated stress

2015

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“…However, less is known about the effects of repeated stress on mesocorticolimbic dopamine activity. Depending on the intensity, duration, frequency, controllability, and predictability of the stressor, some have found repeated stress causes a habituation (Imperato et al 1992; Imperato et al 1993), sensitization (Jordan et al 1994; Naef et al 2013; Petty et al 1997), or no change (Young 2004) in extracellular mPFC or NAcSh dopamine in response to the same stressor.…”

Section: Introductionmentioning

confidence: 99%

Increased mesocorticolimbic dopamine during acute and repeated social defeat stress: modulation by corticotropin releasing factor receptors in the ventral tegmental area

2015

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Rationale Stress activates a subset of dopamine neurons in the ventral tegmental area (VTA), increasing extracellular dopamine in the medial prefrontal cortex (mPFC) and nucleus accumbens shell (NAcSh). The stress neuropeptide corticotropin releasing factor (CRF) and its receptors (CRF-R1 and CRF-R2) are located within the VTA and directly and indirectly influence dopaminergic activity. However, it has yet to be shown in vivo whether VTA CRF receptor activation is necessary for acute and repeated stress-induced dopamine efflux. Objective With intra-VTA CRF-R1 and CRF-R2 antagonism during social defeat, we assessed whether blockade of these receptors could prevent stress-induced dopamine increases in the mPFC and NAcSh using in vivo microdialysis. Methods Rats were microinjected with a CRF-R1 or CRF-R2 antagonist into the VTA prior to social defeat stress on days 1, 4, 7, and 10. In vivo microdialysis for dopamine in the mPFC and NAcSh was performed during stress on days 1 and 10. Results During the first social defeat, extracellular dopamine was significantly elevated in both the mPFC and NAcSh, and this increase in the NAcSh was blocked by intra-VTA CRF-R2, but not CRF-R1, antagonism. During the final social defeat, the dopaminergic increase was neither sensitized nor habituated in the mPFC and NAcSh, and intra-VTA CRF-R2, but not CRF-R1, antagonism prevented the dopamine increase in both brain regions. Conclusion These findings show that CRF-R2 in the VTA is necessary for acute and repeated stress-induced dopamine efflux in the NAcSh, but is only recruited into mPFC-projecting dopamine neurons with repeated stress exposure.

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Infralimbic kappa opioid and muscarinic M1 receptor interactions in the concurrent modulation of anxiety and memory

Wall

Messier

2002

Psychopharmacology

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(1) The effects of IL infusions of norBNI or pirenzepine (10 nmol/0.5 microl) alone on anxiety-like behaviour and aversive learning and memory in the elevated plus-maze replicated previously reported data. (2) Mixed M1/kappa receptor inhibition in the IL cortex exerted counteractive effects on anxiety-like behaviour and aversive learning in the elevated plus maze. (3) Mixed M1/kappa receptor inhibition appeared to exert additive disruptive effects on alternation performance and aspects of attention related to active working memory in the Y-maze.

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Untitled

Cited by 25 publications

References 11 publications

Ventral tegmental area dopamine revisited: effects of acute and repeated stress

Ventral tegmental area dopamine revisited: effects of acute and repeated stress

Increased mesocorticolimbic dopamine during acute and repeated social defeat stress: modulation by corticotropin releasing factor receptors in the ventral tegmental area

Infralimbic kappa opioid and muscarinic M1 receptor interactions in the concurrent modulation of anxiety and memory

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