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Page, Bernard; Vieillard‐Baron, Antoine; Chergui, Karim; Peyrouset, Olivier; Rabiller, Anne; Beauchet, Alain; Aegerter, Philippe; Jardin, François

doi:10.1186/cc3886

Cited by 46 publications

(12 citation statements)

References 31 publications

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“…The general mortality rate was 2.6%. The mortality rate was much lower than the general mortality rate of MOF patients caused by sepsis or trauma, which was approximately 50%, and nearly 100% when more than 4 organs failed [1] , [2] . In our 156 MOF patients, 118 cases had 2 failing organs, 21 cases had 3 failing organs, 16 cases had 4 failing organs, and 1 case had 5 failing organs; there were 17 cases that required mechanical ventilation, 15 cases had acute heart failure, 13 cases had shock, 10 cases had a coma, and 10 cases had cardiac arrest.…”

Section: Discussionmentioning

confidence: 74%

“…(b) Neodevelopment of azotemia (serum creatinine increased over 50%) [4] , [7] , [8] , [10] . The MOF was diagnosed when the patient had two or more dysfunctional organs [1] , [2] , [6] .…”

Section: Clinical Data and Methodsmentioning

confidence: 99%

“…Multiple organ failure (MOF) is a critical condition with a greater than 50% mortality rate [1] , [2] . Raw fish gallbladder with bile has long been used as a folk remedy in Asia, especially in China, to treat such symptoms as decreased visual acuity, asthma, and pain.…”

Section: Introductionmentioning

confidence: 99%

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Clinical analysis of 156 cases of multiple organ failure caused by fish bile

et al. 2015

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ObjectiveTo analyze the clinical features and prognosis of patients suffering from fish bile poisoning.MethodsA total of 156 multiple organ failure (MOF) patients caused by fish bile poisoning were hospitalized in our department over the past 28 years. The patients’ symptoms, examination results, treatment and outcomes were collected and analyzed.ResultsAll patients’ first symptom was gastrointestinal discomfort, including unbearable nausea and intractable vomiting. The symptoms that followed were oliguria or anuria, edema, headache, fatigue, jaundice, palpitation, alimentary tract hemorrhage, gross hematuria, dyspnea, shock, tachycardia, bradycardia, arrhythmia, coma, and cardiac arrest. The symptom severity and cohort were different among different patients. Twenty-one cases received gastroscopy, which exhibited diffuse gastric mucosal bleeding. Twelve patients received renal biopsy, which exhibited focal necrosis of tubular epithelial cells. One patient received a liver biopsy, which exhibited extensive hepatocyte necrosis. All patients received blood purification therapy. Of the four patients who died, 4 out of 5 organs had failed. The general mortality rate was 2.6%.ConclusionsCompared with the MOF caused by trauma and sepsis, the fish bile poisoning MOF has a much lower morality rate. However, patients with higher age, more underlying diseases, and more organ failure tended to have a worse prognosis.

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Section: Discussionmentioning

confidence: 74%

“…(b) Neodevelopment of azotemia (serum creatinine increased over 50%) [4] , [7] , [8] , [10] . The MOF was diagnosed when the patient had two or more dysfunctional organs [1] , [2] , [6] .…”

Section: Clinical Data and Methodsmentioning

confidence: 99%

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Clinical analysis of 156 cases of multiple organ failure caused by fish bile

et al. 2015

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“…This finding is congruent with some data that have shown that failure to correct metabolic acidosis rapidly during CRRT is a strong predictor of mortality. For example, Page et al [ 8 ] have demonstrated that metabolic acidosis was associated with increased lactate levels mainly resulting from circulatory failure. In another study, lactate was shown to be associated with early (48 hours) mortality in patients in need of CRRT by Kawarazaki et al [ 16 ] The authors suggested that lactate, among other variables, could help differentiate acute kidney injury patients who do not benefit from CRRT.…”

Section: Discussionmentioning

confidence: 99%

“…[ 7 ] In patients with septic AKI the lack of improvement of acidosis on CRRT is associated with increased lactate levels, circulatory failure, and high mortality. [ 8 ] Lactate clearance early in the hospital course may indicate a resolution of global tissue hypoxia and is associated with decreased mortality rate in patients with severe sepsis and septic shock, [ 9 ] so lactate clearance has been used as one of the goals of early sepsis resuscitation; [ 10 ] however, it is not clear if these data apply to septic patients in need of CRRT.…”

Section: Introductionmentioning

confidence: 99%

Lactate clearance is associated with mortality in septic patients with acute kidney injury requiring continuous renal replacement therapy

et al. 2016

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The aim of the study was to assess the clinical utility of lactate measured at different time points to predict mortality at 48 hours and 28 days in septic patients with acute kidney injury (AKI) requiring continuous renal replacement therapy (CRRT).Consecutive critically ill patients with septic AKI requiring CRRT were prospectively studied. Variables were collected at initiation of CRRT and 24 hours later.In total, 186 patients were analyzed. Overall mortality at 48 hours was 28% and at 28 days was 69%. Initial lactate, lactate at 24 hours and the proportion of patients with a lactate clearance superior to 10% were different between survivors at 28 days [2.0 mmol/L, 1.95 mmol/L and 18/45 (40%)] and nonsurvivors [3.46 mmol, 4.66 mmol, and 18/94 (19%)]. Multivariate analysis demonstrated that lactate at 24 hours and lactate clearance, but not initial lactate, were independently associated to mortality. Area under the ROC curves for 28-day mortality was 0.635 for initial lactate; 0.828 for lactate at 24 hours and 0.701 for lactate clearance.Lactate clearance and lactate after 24 hours of CRRT, but not initial lactate, were independently associated with mortality in septic AKI patients undergoing CRRT. Serial lactate measurements may be useful prognostic markers than initial lactate in these patients.

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