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Hanson, Robert L.; Browne, Gary; Fasher, B; Mcaskill, M; Moroney, Paul; Hawker, Richard E.

doi:10.1016/s0022-3476(97)70337-8

Cited by 18 publications

(1 citation statement)

References 5 publications

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“…But it is not without side‐effects. It is associated with lengthening of the electrocardiographic QT interval in high doses 15 , 16 . Erythromycin, clarithromycin, flucanazole, ketoconazole and miconazole, inhibit the metabolic inactivation of cisapride and hence it should not be used with those agents.…”

Section: Discussionmentioning

confidence: 99%

Cisapride and Caesarean section: Their role in babies with gastroschisis

Kumar

Shi

Duffy

1999

J Paediatrics Child Health

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Section: Discussionmentioning

confidence: 99%

Cisapride and Caesarean section: Their role in babies with gastroschisis

Kumar

Shi

Duffy

1999

J Paediatrics Child Health

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Risk of QT Prolongation and Torsades de Pointes with Prokinetics and Miscellaneous other Drugs

Yap¹,

Malik²

2004

Acquired Long QT Syndrome

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The Role of Cisapride in the Treatment of Pediatric Gastroesophageal Reflux

Vandenplas,

Belli,

Benatar

et al. 1999

J. pediatr. gastroenterol. nutr.

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Background:Cisapride is a gastrointestinal prokinetic agent that is used worldwide in the treatment of gastrointestinal motility‐related disorders in premature infants, full‐term infants, and children. Efficacy data suggest that it is the most effective commercially available prokinetic drug.Methods:Because of recent concerns about safety, a critical and in‐depth analysis of all reported adverse events was performed and resulted in the conclusions and recommendations that follow.Results:Cisapride should only be administered to patients in whom the use of prokinetics is justified according to current medical knowledge. If cisapride is given to pediatric patients who can be considered healthy except for their gastrointestinal motility disorder, and the maximum dose does not exceed 0.8 mg/kg per day in 3 to 4 administrations of 0.2 mg/kg (not exceeding 40 mg/d), no special safety procedures regarding potential cardiac adverse events are recommended. However, if cisapride is prescribed for pateints who are known to be or are suspected of being at increased risk for drug‐associated increases in QTc interval, certain precautions are advisable. Such patients include those:(1) with a previous history of cardiac dysrhythmias, (2) receiving drugs known to inhibit the metabolism of cisapride and/or adversely affect ventricular repolarisation, (3) with immaturity and/or disease causing reduced cytochrome P450 3A4 activity, or (4) with electrolyte disturbances. In such patients, ECG monitoring to quantitate the QTc interval should be used before initiation of therapy and after 3 days of treatment to ascertain whether a cisapride‐induced cardiac adverse effect is present.Conclusions:With rare exceptions, the total daily dose of cisapride should not exceed 0.8 mg/kg divided into 3 or 4 approximately equally spaced doses. If higher doses than this are given, the precautions above are advisable. In any patient in whom a prolonged QTc interval is found, the dose of cisapride should be reduced or the drug discontinued until the ECG normalizes. If the QTc interval returns to normal after withdrawal of cisapride, and the administration of cisapride is considered to be justified because of its efficacy and absence of alternative treatment options, cisapride can be restarted at half dose with control of the QTc interval. Unfortunately, at present, normal ranges of QTc interval in children are unknown. However, a critical analysis of the literature suggests that a duration of less than 450 milliseconds can be considered to be within the normal range and greater than 470 milliseconds as outside it.

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Untitled

Cited by 18 publications

References 5 publications

Cisapride and Caesarean section: Their role in babies with gastroschisis

Cisapride and Caesarean section: Their role in babies with gastroschisis

Risk of QT Prolongation and Torsades de Pointes with Prokinetics and Miscellaneous other Drugs

The Role of Cisapride in the Treatment of Pediatric Gastroesophageal Reflux

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