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Abstract

Nocturnal Enuresis treatment activity in rabbits by measuring the changes in urine volume and concentrations of electrolytes as well as bladder capacities. In addition, antioxidant activity was measured using free radical scavenging (DPPH method) and antimicrobial activity against human bacterial pathogens using agar diffusion technique. Pandanus Odoratissimus L. peduncle showed no toxic effect with a predicted lethal dose > 16g/kg. The findings indicate the peduncle extracts increase the capacity of the bladder which is an indicator of muscle relaxation with no direct effect on the muscle of dissected bladders. The methanolic extract of the peduncle decrease the urine volume both at 24 hrs and as prescribed traditionally in Yemen (for 3 days) with no effect on its electrolytes. In addition, antioxidant activity of the methanolic peduncle extract was evident by the 83% inhibition of DPPH with different concentrations of the extracts as compared with Vitamin C. In contrast, Peduncle extracts showed no antimicrobial activity against five standard microbial strains (Micrococcus Lit, Staphlococcus aureus, Escherichia coli, Salmonella enteritidis and Candida albicans). In conclusion, the methanolic peduncle extract of Pandanus Odoratissimus L. shows potential Nnocturnal enuresis and antioxidant activities and lacks the antimicrobial activity.