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CASTAIGNE, CATHERINE; Martin, Philippe; BLOCKLET, DIDIER

doi:10.1097/00003072-200306000-00003

Cited by 5 publications

(6 citation statements)

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“…Kanoh et al performed gastric biopsies in a patient with myeloma that demonstrated amyloid deposits, and it was hypothesized that this was the cause of the observed activity ( 5 ). Pulmonary uptake of MDP has also been described in hypercalcemia ( 7 ), and we take this to be the cause in this case.…”

Section: Discussionmentioning

confidence: 75%

Marked gastric uptake of Tc-99m methylene diphosphonate (MDP) in a patient with myeloma and hypercalcemia

Foley¹,

Fielding²

2012

Radiology Case Reports

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A 59-year-old man presented with a 7-month history of increasing left shoulder pain. The initial plain films showed near absence of the left scapula and scattered lucent changes in the left humerus. A CT scan confirmed the presence of widespread lytic bony lesions, with a large soft-tissue mass centered around the left scapula. An isotope bone scan demonstrated marked uptake of MDP in the stomach and nasal mucosa. Further laboratory investigations revealed marked hypercalcemia and the presence of Bence-Jones protein in the urine. An ultrasound-guided biopsy of the soft-tissue mass confirmed the diagnosis of multiple myeloma.

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Section: Discussionmentioning

confidence: 75%

Marked gastric uptake of Tc-99m methylene diphosphonate (MDP) in a patient with myeloma and hypercalcemia

Foley¹,

Fielding²

2012

Radiology Case Reports

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“…The interesting point of our case was the calcium deposition in the gastric mucosa, which was found by bone scintigraphy and confirmed by a histological examination. Detection of visceral metastatic calcification by bone scintigraphy with 99m Tc-phosphate complexes has often been reported in cases of hypercalcemia (3,4). However, there are few cases in which metastatic calcification was proven histologically, and most were autopsy cases without any follow-up of their clinical course (3,5,6).…”

Section: Discussionmentioning

confidence: 99%

A Reversible Gastric Uptake of Bone Scintigraphy in a Patient with Hypercalcemia

et al. 2019

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Hypercalcemia is a severe complication in cases of vitamin D intoxication that can result in metastatic calcification. We herein report a female case with hypercalcemia due to eldecalcitol administration associated with the increased uptake of technetium-99m hydroxymethylene diphosphonate ( 99m Tc-HMDP) as the bone-scanning agent in the stomach. A histologic assessment using biopsy specimens identified metastatic calcification of the stomach. After the normalization of serum calcium levels, the gastric uptake of 99m Tc-HMDP disappeared. This case indicates the usefulness of bone scintigraphy with 99m Tc-HMDP to detect visceral metastatic calcification and to monitor its therapeutic effects in patients with hypercalcemia.

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“…Because metastatic calcifications are frequently found in lung, kidney, and stomach, it has been noted that the secretion of free hydrogen ions is an important local factor in the development of metastatic calcification. These organs secrete lots of free hydrogen ions and create an alkaline environment, which can induce the deposition of calcium salts [13, 14]. …”

Section: Discussionmentioning

confidence: 99%

Rapid development of metastatic pulmonary calcifications in primary hyperparathyroidism: a case report and literature review

et al. 2017

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BackgroundMetastatic pulmonary calcification (MPC) is rarely reported in primary hyperparathyroidism, especially MPC develops quickly. We report such a case here with a literature review.Case presentationA 41-year-old woman presented with cough and dyspnea. Data from clinical, radiological, pathological, technetium (99mTc)-methylene diphosphonate (MDP) bone scintillation imaging, and 99mTc-methoxy isobutyl isonitrile (MIBI) thyroid imaging were studied. 99mTc-MIBI thyroid imaging indicated hyperparathyroidism. Chest computed tomography (CT) scans showed rapidly progressive bilateral pulmonary multiple high-density shadows with mass consolidation and exudation in only five days. 99mTc-MDP bone scintillation imaging indicated bilateral pulmonary calcifications. CT-guided lung biopsy showed multifocal irregularities of calcium deposition and calcified bodies in the pulmonary interstitium. The patient showed gradually clinical and radiological improvement after surgical removal of the parathyroid adenoma.ConclusionRapidly progressive MPC tends to be misdiagnosed as many primary pulmonary diseases. 99mTc-MDP bone scintillation imaging and pulmonary biopsy could be performed to differentiate metastatic pulmonary calcification from other diseases. Surgical resection of the parathyroid gland is helpful for treatment of MPC in patients with primary hyperparathyroidism and is regularly recommended.

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Untitled

Cited by 5 publications

References 0 publications

Marked gastric uptake of Tc-99m methylene diphosphonate (MDP) in a patient with myeloma and hypercalcemia

Marked gastric uptake of Tc-99m methylene diphosphonate (MDP) in a patient with myeloma and hypercalcemia

A Reversible Gastric Uptake of Bone Scintigraphy in a Patient with Hypercalcemia

Rapid development of metastatic pulmonary calcifications in primary hyperparathyroidism: a case report and literature review

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