Untitled

Sentamilselvi, G; Janaki, C; Kamalam, A.; Thambiah, A. S.

doi:10.1023/a:1006984116046

Cited by 21 publications

(3 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Some published cases were compatible with deep or extensive dermatophytosis but lacked mycological confirmation [ 31 , 93 , 94 ]. In other published cases, there was no identified predisposing condition [ 28 , 95 , 96 , 97 , 98 , 99 , 100 , 101 , 102 , 103 , 104 , 105 , 106 , 107 , 108 , 109 , 110 ]. However underlying immunodeficiency cannot be excluded in these patients without thorough immunological investigations.…”

Section: Underlying Conditions Responsible For Severe Dermatophytsmentioning

confidence: 96%

Severe Dermatophytosis and Acquired or Innate Immunodeficiency: A Review

Rouzaud

Hay

Chosidow

et al. 2015

JoF

106

View full text Add to dashboard Cite

Dermatophytes are keratinophilic fungi responsible for benign and common forms of infection worldwide. However, they can lead to rare and severe diseases in immunocompromised patients. Severe forms include extensive and/or invasive dermatophytosis, i.e., deep dermatophytosis and Majocchi’s granuloma. They are reported in immunocompromised hosts with primary (autosomal recessive CARD9 deficiency) or acquired (solid organ transplantation, autoimmune diseases requiring immunosuppressive treatments, HIV infection) immunodeficiencies. The clinical manifestations of the infection are not specific. Lymph node and organ involvement may also occur. Diagnosis requires both mycological and histological findings. There is no consensus on treatment. Systemic antifungal agents such as terbinafine and azoles (itraconazole or posaconazole) are effective. However, long-term outcome and treatment management depend on the site and extent of the infection and the nature of the underlying immunodeficiency.

show abstract

Section: Underlying Conditions Responsible For Severe Dermatophytsmentioning

confidence: 96%

Severe Dermatophytosis and Acquired or Innate Immunodeficiency: A Review

Rouzaud

Hay

Chosidow

et al. 2015

JoF

106

View full text Add to dashboard Cite

show abstract

“…Trichophyton rubrum is a filamentous fungus found throughout the world that can infect human keratinized tissue (skin, nails and, rarely, hair), and is the causal agent of 80–90 % of all chronic and recurrent dermatophytoses (Costa et al , 2002; Jennings et al , 2002; Monod et al , 2002). This pathogen, which normally causes well-characterized superficial infections, also produces skin infections in unusual parts of the body in immunosuppressed patients (Sentamilselvi et al , 1998; Smith et al , 2001; Squeo et al , 1998). Although not normally life-threatening, dermatophyte infections are often difficult to eliminate completely and they have a 25–40 % recurrence rate (Sentamilselvi et al , 1998).…”

Section: Introductionmentioning

confidence: 99%

“…This pathogen, which normally causes well-characterized superficial infections, also produces skin infections in unusual parts of the body in immunosuppressed patients (Sentamilselvi et al , 1998; Smith et al , 2001; Squeo et al , 1998). Although not normally life-threatening, dermatophyte infections are often difficult to eliminate completely and they have a 25–40 % recurrence rate (Sentamilselvi et al , 1998). Additionally, resistance to antifungal drugs poses an increasing problem in clinical treatment; over the past decade, an increasing number of cases of azole- and terbinafine-resistant dermatophyte infections have been reported (Fachin et al , 1996; Smith et al , 2001).…”

Section: Introductionmentioning

confidence: 99%

Analysis of gene expression changes in Trichophyton rubrum after skin interaction

Liu

Leng

et al. 2014

Journal of Medical Microbiology

View full text Add to dashboard Cite

Trichophyton rubrum, an anthropophilic and cosmopolitan fungus, is the most common agent of superficial mycoses. In this study, T. rubrum infection was modelled by adding human skin sections to a limited medium containing glucose and cDNA microarrays were used to monitor T. rubrum gene expression patterns on a global level. We observed that exposure to human skin resulted in upregulation of the expression levels of T. rubrum genes related to many cellular and biological processes, including transcription and translation, metabolism and secondary transport, the stress response, and signalling pathways. These results provide a reference set of T. rubrum genes whose expression patterns change upon infection and reveal previously unknown genes that most likely correspond to proteins that should be considered as virulence factor candidates and potential new drug targets for T. rubrum infection.

show abstract

Infection Risk by Dermatophytes During Storage and After Domestic Laundry and Their Temperature-Dependent Inactivation

2010

View full text Add to dashboard Cite

In the developed countries infections of the feet (tinea pedis, athlete's foot) and nails (onychomycosis) with the anthropophile fungus Trichophyton rubrum are most common. We examined the propagation of dermatophytes before and during domestic laundering. About 10% of the infectious material was transferred from contaminated textiles to sterile textiles during storage in a clothes basket simulation indicating a high infection risk during storage. This was evaluated with two quantification techniques: cultivation with subsequent colony counting and tracing of radioactively labelled propagating units. Both approaches reliably revealed similar results with the latter method reducing experimental time to few minutes compared to 2 weeks with the traditional method. The tracer technique allowed favourably to directly reflect the textile-bound infectious material at the moment of skin contact. To address the infection risk during domestic laundry, bioindicators with T. rubrum or the yeast Candida albicans were introduced into common domestic washing procedures with different temperature courses. While C. albicans did not survive any of the tests, T. rubrum could be recovered after washing at 30°C, indicating the risk potential of dermatophyte infections at home. Up to 16% of the initial fungus load was detected in the rinsing water. Washing at 60°C however, eliminated both pathogens, T. rubrum and C. albicans.

show abstract

Untitled

Abstract: A case of deep dermatophytosis in the gluteal region in a male patient successfully treated with terbinafine is described with its clinical, mycological and histopathological features.

Cited by 21 publications

References 2 publications

Severe Dermatophytosis and Acquired or Innate Immunodeficiency: A Review

Severe Dermatophytosis and Acquired or Innate Immunodeficiency: A Review

Analysis of gene expression changes in Trichophyton rubrum after skin interaction

Infection Risk by Dermatophytes During Storage and After Domestic Laundry and Their Temperature-Dependent Inactivation

Contact Info

Product

Resources

About