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Synthesis and anticancer activity of quinopimaric and maleopimaric acids’ derivatives

“…4 Many intensive studies were focused on the antibacterial activity of abietic and levopimaric acids, especially on the interaction of abietic acid with zinc oxide, rosin and other resin acids and their combination. 5 In vivo experiments have shown that diene adducts of levopimaric acid and its derivatives possess an anti-inflammatory, 6 antiulcer, 7 and antiviral activities. 8 Abietic and levopimaric acids are the major components of rosin (colophony) and can be extracted from Pinus rosin or commercial disproportionate rosin.…”

Click chemistry on diterpenes: anti-inflammatory activity of the acetylenic derivatives of levopimaric acid and products of their transformations

“…Furthermore, the recently reported adducts of LpA with benzoquinones display activity comparable with orthophen. 7 The derivatives of dihydroquinopimaric acid show a particularly attractive combination of high antiinflammatory activity with low toxicity. 8 These examples illustrate the potential of abietic diterpenoids as a structural scaffold in the design of anti-inflammatory agents.…”

Synthesis of 5-Hydroxy-1,3-benzoxathiol-2-one and 2-Amino-1,3-benzothiazol-6-ol Derivatives from Chrysenequinonecarboxylic Acid

“…exhibit insecticide and fungicide properties [5,6]. In continuation of our studies on the synthesis of heterocycles with a diterpenoid fragment [2,[7][8][9], in the present work we synthesized derivatives of 5-hydroxy-1,3-benzoxathiol-2-one and 2-amino-1,3-benzothiazol-6-ol on the basis of quinopimaric acid, an adduct of levopimaric acid and p-benzoquinone.…”

“…Resin acids and their derivatives exhibit biological activity; for example, levopimaric acid adducts with 1,4-benzoquinone, 2-acetaminoquinone, sulfonaphthoquinone, and 3-hexylsulfanyl-4,5-dihydrothiophen-4-one 1,1-dioxide show antiulcer and antiphlogistic activity [1][2][3], while diarylamino derivatives of dehydroabietic acid act as antioxidants [4]. Some diterpenoid indole alkaloids (paspaline, penitrem, terpendole, etc.)…”