Paranormal and mystical experiences challenge reductionism and ultra-reductionism-the assumption that the whole is the same as the sum of its parts. Quantum is the bedrock of matter, but mysticism is the bedrock of reality. In this respect, studies of mysticism are an unavoidable part of a scientific quest.The study of near-death experiences (NDEs) has brought the exploration of post-mortem existence to the scientific arena. Similarly, studies of Marian apparitions could be bringing mysticism to the realm of the scientific imagination. From a spiritual and scientific perspective, the ongoing Marian apparitional occurrences in Medjugorje (Bosnia) are highly valuable. Ultra-reductionism is a serious challenge, and this can be addressed by exploring mysticism. Self-realization, discarnate existence, and God realization are important aspects of spirituality. Death-related visions offer evidence of an extended consciousness and its survival after physical extinction, but additionally, Marian mysticism illuminates us of the Heavenly realities and contributes meaning to terrestrial existence. In view of the accumulating evidence in favor of the reality of discarnate existence, the medical viewpoint toward assisted suicide needs to be morally evaluated. Terminal illness and the final years of life become transitional preparatory periods, whereby we disengage with the pleasant and unpleasant illusions of earthly existence, which could turn out to be spiritually productive.