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Kaise, Mitsuru; Miwa, Jun; Iihara, Kuniko; Suzuki, Nobuaki; Oda, Y.; Ohta, Yasuhiko

doi:10.1023/a:1022855818944

Cited by 14 publications

(4 citation statements)

References 38 publications

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“…Increased activity of iNOS and high levels of KC and IL-1β have been observed in the gastric mucosa of patients with chronic gastritis and gastric adenocarcinoma [46]. Neutrophil infiltration is positively correlated with the expression of iNOS and inflammatory cytokines in gastric mucosa [47]. These studies showed that the upregulation of iNOS, KC, and IL-1β by H. pylori infection might be associated with neutrophil infiltration.…”

Section: Discussionmentioning

confidence: 72%

Protective effect of Korean Red Ginseng extract against Helicobacter pylori-induced gastric inflammation in Mongolian gerbils

Bae

Jang

Lim

et al. 2014

Journal of Ginseng Research

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Helicobacter pylori-induced gastric inflammation includes induction of inflammatory mediators interleukin (IL)-8 and inducible nitric oxide synthase (iNOS), which are mediated by oxidant-sensitive transcription factor NF-κB. High levels of lipid peroxide (LPO) and increased activity of myeloperoxidase (MPO), a biomarker of neutrophil infiltration, are observed in H. pylori-infected gastric mucosa. Panax ginseng Meyer, a Korean herb medicine, is widely used in Asian countries for its biological activities including anti-inflammatory efficacy. The present study aims to investigate whether Korean Red Ginseng extract (RGE) inhibits H. pylori-induced gastric inflammation in Mongolian gerbils. One wk after intragastric inoculation with H. pylori, Mongolian gerbils were fed with either the control diet or the diet containing RGE (200 mg RGE/gerbil) for 6 wk. The following were determined in gastric mucosa: the number of viable H. pylori in stomach; MPO activity; LPO level; mRNA and protein levels of keratinocyte chemoattractant factor (KC, a rodent IL-8 homolog), IL-1β, and iNOS; protein level of phospho-IκBα (which reflects the activation of NF-κB); and histology. As a result, RGE suppressed H. pylori-induced mRNA and protein levels of KC, IL-1β, and iNOS in gastric mucosa. RGE also inhibited H. pylori-induced phosphorylation of IκBα and increases in LPO level and MPO activity of gastric mucosa. RGE did not affect viable H. pylori colonization in the stomach, but improved the histological grade of infiltration of polymorphonuclear neutrophils, intestinal metaplasia, and hyperplasia. In conclusion, RGE inhibits H. pylori-induced gastric inflammation by suppressing induction of inflammatory mediators (KC, IL-1β, iNOS), MPO activity, and LPO level in H. pylori-infected gastric mucosa.

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Section: Discussionmentioning

confidence: 72%

Protective effect of Korean Red Ginseng extract against Helicobacter pylori-induced gastric inflammation in Mongolian gerbils

Bae

Jang

Lim

et al. 2014

Journal of Ginseng Research

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“…In patients with gastritis, especially those infected with H. pylori , nitric oxide produced by inducible nitric oxide synthase(iNOS) and COX-2 is induced to regulate epithelial cell growth and inflammatory changes ( 84 ). Studies have underscored the significance of iNOS as an inflammation-inducing enzyme and a key contributing factor to gastritis ( 85 ). Furthermore, iNOS can bind to H. pylori and induce apoptosis in gastric mucosal.…”

Section: Inflammatory Molecules and Microorganisms Regulation In Gast...mentioning

confidence: 99%

Inflammatory microenvironment in gastric premalignant lesions: implication and application

Zhang,

Shen,

Liu

et al. 2023

Front. Immunol.

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Gastric precancerous lesions (GPL) are a major health concern worldwide due to their potential to progress to gastric cancer (GC). Understanding the mechanism underlying the transformation from GPL to GC can provide a fresh insight for the early detection of GC. Although chronic inflammation is prevalent in the GPL, how the inflammatory microenvironment monitored the progression of GPL-to-GC are still elusive. Inflammation has been recognized as a key player in the progression of GPL. This review aims to provide an overview of the inflammatory microenvironment in GPL and its implications for disease progression and potential therapeutic applications. We discuss the involvement of inflammation in the progression of GPL, highlighting Helicobacter pylori (H. pylori) as a mediator for inflammatory microenvironment and a key driver to GC progression. We explore the role of immune cells in mediating the progression of GPL, and focus on the regulation of inflammatory molecules in this disease. Furthermore, we discuss the potential of targeting inflammatory pathways for GPL. There are currently no specific drugs for GPL treatment, but traditional Chinese Medicine (TCM) and natural antioxidants, known as antioxidant and anti-inflammatory properties, exhibit promising effects in suppressing or reversing the progression of GPL. Finally, the challenges and future perspectives in the field are proposed. Overall, this review highlights the central role of the inflammatory microenvironment in the progression of GPL, paving the way for innovative therapeutic approaches in the future.

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“…Inflammatory conditions in the gastric mucosa are characterized by activation of NF-κ B, resulting in the expression of NF-κ B-regulated, inflammatory-inducible genes, such as inducible nitric oxide synthase (iNOS) and cyclo-oxygenase-2 (COX-2) [ 10 ]. Elevated expression of iNOS and increased nitric oxide synthesis are a hallmark of the inflammatory reaction in H. pylori -induced gastritis [ 12 ]. Studies have shown that a constitutive overproduction of iNOS and, hence, of nitric oxide may lead to DNA and protein damage, which could increase the risk of development of cancer [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Association between self-rated depressive symptoms and mucosal expression of NF-κ B in patients with upper gastrointestinal symptoms

Staab

Vonhören

Schwörer

et al. 2023

BioPsychoSocial Med

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Background Previous clinical studies have reported elevated levels of depressive symptoms in selected samples of patients with gastritis. The objective of this study was to examine the associations of specific biomarkers of inflammation expressed in mucosal tissue from the stomach with mood and anxiety symptoms in adult patients with upper gastrointestinal symptoms. Methods In this monocentric, observational study, a total of 32 study participants were included who were referred for a routine diagnostic upper endoscopic assessment based on the suspected clinical diagnosis of gastritis. All participants completed the Hospital Anxiety and Depression Scale (HADS) before undergoing gastroscopy. Immunohistochemical stainings from biopsy sections were performed to evaluate the expression level of nuclear factor kappa B (NF-κ B), myeloperoxidase (MPO) and inducible nitric oxide synthase (iNOS). Results Our findings confirmed that nearly half of the study cohort (n = 13; 41%) displayed positive HADS depression scores above the clinically relevant cut-off level of ≥ 8. Regression models demonstrated that depressive symptoms were significantly and positively associated with the expression level of NF-κ B in biopsies from the upper gastrointestinal tract. Conclusions In summary, our study showed a significant association between NF-κ B expression and clinically relevant depressive symptoms in patients with gastritis, as assessed by a self-rated psychometric questionnaire. Further investigations are needed to confirm this relationship and to identify the pathophysiological mechanisms involved.

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Untitled

Cited by 14 publications

References 38 publications

Protective effect of Korean Red Ginseng extract against Helicobacter pylori-induced gastric inflammation in Mongolian gerbils

Protective effect of Korean Red Ginseng extract against Helicobacter pylori-induced gastric inflammation in Mongolian gerbils

Inflammatory microenvironment in gastric premalignant lesions: implication and application

Association between self-rated depressive symptoms and mucosal expression of NF-κ B in patients with upper gastrointestinal symptoms

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