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Jäppinen, Annaliisa; Kokki, Hannu; Naaranlahti, Toivo; Rasi, Anu

doi:10.1023/a:1008771621812

Cited by 9 publications

(3 citation statements)

References 6 publications

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“…Eighteen of the included studies investigated compatibility at ambient temperature (18–25°C)[ 13 – 21 , 25 – 29 , 31 – 34 ], eleven also investigated compatibility at refrigerated temperature (4–8°C)[ 15 , 18 – 21 , 25 – 28 , 31 , 32 ], five investigated at body temperature (36–38°C)[ 13 , 15 , 25 , 32 , 35 ] and two studies investigated compatibility at 32°C, simulating a syringe held in a sling close to the patients’ body[ 24 , 30 ].…”

Section: Resultsmentioning

confidence: 99%

“…All studies, bar one (Destro et al [ 33 ]), as a minimum used a mean of replicate results and standard deviation or better for analysing the chemical compatibility and stability of the drug combination investigated by HPLC. One study[ 25 ] investigated the microbiological stability of the solutions tested over a 30-day period using the technique of membrane filtration to European Pharmacopoeia standards.…”

Section: Resultsmentioning

confidence: 99%

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The current evidence base for the feasibility of 48-hour continuous subcutaneous infusions (CSCIs): A systematically-structured review

et al. 2018

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BackgroundA continuous subcutaneous infusion (CSCI) is an effective method of multiple drug administration commonly encountered in end of life care when the oral route is compromised. At present, current practice is to limit syringe driver infusion time to a maximum of 24 hours as dictated by available chemical stability data. However, the ability to deliver prescribed medication by a CSCI over 48 hours may have numerous benefits in both patient care and health service resource utilisation.AimTo examine and present the current evidence base for the stability of 48-hour multiple-drug CSCIs in current clinical practice.DesignA systematically-structured review following PRISMA guidelines.Data sourcesThree electronic databases and the grey literature were searched with no time limits. Empirical studies reporting data on the chemical stability of continuous subcutaneous infusions or solutions stored in polypropylene syringes were included.ResultsTwenty-one empirical studies were included in this review reporting chemical compatibility and stability of 32 discrete combinations of twenty-four drugs tested at a variety of different drug concentrations. The majority of combinations reported were assessed as being chemically compatible. The greatest risk of clinically significant chemical degradation was observed with midazolam. Only one study reported the microbiological stability of the solution examined.ConclusionsThere is currently limited evidence for the physical, chemical and microbiological stability of solutions for continuous subcutaneous infusion over a period of 48 hours. More stability data is required before the use of 48-hour CSCIs can be evaluated for use within clinical practice.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

The current evidence base for the feasibility of 48-hour continuous subcutaneous infusions (CSCIs): A systematically-structured review

et al. 2018

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“…From the viewpoint of a clinical anesthetist, online detection methods that facilitate measuring ropivacaine concentrations are critical. 6 N-H was revealed on the surface of Ppy, and the N-H, O-H, and C=O functional groups were present on the surface of the Ppy/1% GO sample. 7 Ppy/GO composites exhibit stronger thermal stability and electrical conductivity levels compared with pure Ppy.…”

Section: Introductionmentioning

confidence: 96%

Online Detection of Ropivacaine in Drip Bags Using Polypyrrole/graphene Oxide Materials

Chen

Luk

et al. 2014

J Chinese Chemical Soc

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A novel method of measuring the concentration of the local anesthetic ropivacaine drip bags used in hospitals was developed using electrochemical impedance technique. Polypyrrole (Ppy)/graphene oxide (GO) composites were prepared by electrochemically polymerization over Au electrodes, which served as working electrodes. The Ppy/GO composite electrodes were characterized using scanning electron microscopy (SEM) and transmission electron microscopy (TEM). Various concentrations of ropivacaine (0.1-20 ppm) were prepared in a sample drip bag solution of 0.9% NaCl from hostpital. The composite Ppy/1% GO electrode exhibited strongest linearity (R 2 = 0.960) than the Ppy electrode (R 2 = 0.928) at a frequency of 100 kHz. The detection limits of ropivacaine on Ppy and Ppy/1% GO were calculated as 0.11 ppm and 0.08 ppm, respectively. The proposed system yielded response and recovery times under 1 sec detecting 0.1 ppm (100 mg/L) of ropivacaine; thus, the proposed online method is promising for measuring ropivacaine concentrations in drip bags. Molecular simulations and equivalent circuits were applied to explain the dynamic behavior of ropivacaine detection system using Ppy and Ppy/GO materials.

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Compatibility of haloperidol and hyoscine-N-butyl bromide in mixtures for subcutaneous infusion to cancer patients in palliative care

Barcia

Reyes

Azuara

et al. 2003

Support Care Cancer

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The administration of drugs by s.c. infusion is routinely practiced in palliative medicine for the management of patients who are no longer able to take oral medication. It is not uncommon for two or more drugs to be combined in s.c. infusion solutions. Unfortunately, the compatibility and stability of haloperidol and hyoscine-N-butyl bromide has not yet been determined. The objective of this study was to study the compatibility and stability of solutions containing both drugs in polypropylene syringes. Nine different solutions were assessed for up to 15 days following preparation. The solutions were prepared in polypropylene syringes with 0.9% saline as a diluent and stored at 4°C and 25°C. High-performance liquid chromatography was the analytical technique used to measure haloperidol and hyoscine-N-butyl bromide. The initial concentration ranges were 0.3125-1.25 mg/ml for haloperidol and 2.5-10.0 mg/ml for hyoscine-Nbutyl bromide. Haloperidol was pre-cipitated at a concentration of ≥1.25 mg/ml when it was combined with hyoscine-N-butyl bromide. Concentrations of hyoscine-N-butyl bromide lower than 10 mg/ml in mixtures with haloperidol or 0.625 mg/ml of haloperidol in mixtures with hyoscine-N-butyl bromide for s.c. infusion allow for the administration of both drugs without any significant loss after storage at 25°C for periods of up to 15 days, with approximately ≥90% and 88%, respectively, of haloperidol and hyoscine-N-butyl bromide remaining. However, after storage of the mixtures for equivalent periods at 4°C the losses of hyoscine-N-butyl bromide observed at the end of the study were higher than 20%, while the percentages of haloperidol remaining after 15 days at this temperature were ≥94.37%.

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Untitled

Cited by 9 publications

References 6 publications

The current evidence base for the feasibility of 48-hour continuous subcutaneous infusions (CSCIs): A systematically-structured review

The current evidence base for the feasibility of 48-hour continuous subcutaneous infusions (CSCIs): A systematically-structured review

Online Detection of Ropivacaine in Drip Bags Using Polypyrrole/graphene Oxide Materials

Compatibility of haloperidol and hyoscine-N-butyl bromide in mixtures for subcutaneous infusion to cancer patients in palliative care

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