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Abstract

Psoriasis is autoimmune, hyperproliferative skin disease, which is affecting 2-5% of the population. Etiology of psoriasis is multifactorial. The disease is identified as periodic recycle of events with redscaly skin plaques. The epidemiology of Psoriasis is still unknown. From medication, this disease can only be prevented. Currently, there are many approaches to cure this disease, but still, no approach has completely cured the illness. New treatments are available for psoriasis, which are derived from biotechnology; they are known as biological drugs. The discovery of these new drugs derived from biotechnology prevents the activation of T-cells and targets cytokines. These drugs are less toxic and better functional, so patients, as well as a dermatologist, prefer the use of these biological drugs for the treatment of psoriasis over topical therapy, phototherapy, and systemic therapy. This review gives a detailed explanation of current therapies for the treatment of psoriasis and challenges associated along with it. INTRODUCTION: Psoriasis is a proliferative disorder of the skin with repeating events of hyperkeratosis and inflammation with the worldwide manifestation around 2-5% 1-3. It is characterized by periodic recycling of red and sharp scaly skin plaques 4. Psoriasis is classified into chronic, plaque, guttate, pustular, and erythroderma. Among all the above types, plaque psoriasis is the major one 5-6. The etiology of this disease is multi-factorial that is the union of both environmental, as well as a genetic factor triggering the immune histological changes noticed in the skin 7. However, the cause of psoriasis is still unknown.